VYNE THERAPEUTICS INC

CUSIP: 92941V100 Class: COM NEW

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2020
Shares 923,759 Value ($000) $1,460 Avg Close — Range —
Q3 2020
Shares 325,000 Value ($000) $540 Avg Close — Range —