VYNE THERAPEUTICS INC

CUSIP: 92941V209 Class: Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021
Shares 81,287 Value ($000) $113 Avg Close — Range —
Q2 2021
Shares 47,025 Value ($000) $165 Avg Close — Range —
Q1 2021
Shares 297,883 Value ($000) $2,039 Avg Close — Range —