VYNE THERAPEUTICS INC

Ticker: VYNE CUSIP: 92941V308 Class: COM

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 72,356 Value ($000) $42 Avg Close $0.40 Range $0.32 - $0.75

Q3 2025

Shares 147,120 Value ($000) $49 Avg Close $0.65 Range $0.28 - $1.96

Q2 2025

Shares 124,822 Value ($000) $206 Avg Close $1.30 Range $0.85 - $1.99

Q4 2024

Shares 20,286 Value ($000) $68 Avg Close $2.62 Range $1.80 - $3.43

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	72,356	$42	$0.40	$0.32 - $0.75
Q3 2025	147,120	$49	$0.65	$0.28 - $1.96
Q2 2025	124,822	$206	$1.30	$0.85 - $1.99
Q4 2024	20,286	$68	$2.62	$1.80 - $3.43