ZYMEWORKS INC

CUSIP: 98985W102 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022
Shares 791,148 Value ($000) $5,182 Avg Close — Range —
Q3 2021
Shares 18,532 Value ($000) $538 Avg Close — Range —
Q1 2021
Shares 123,748 Value ($000) $3,908 Avg Close — Range —
Q4 2020
Shares 64,148 Value ($000) $3,032 Avg Close — Range —
Q2 2020
Shares 130,950 Value ($000) $4,723 Avg Close — Range —
Q1 2020
Shares 271,914 Value ($000) $9,645 Avg Close — Range —
Q4 2019
Shares 378,956 Value ($000) $17,227 Avg Close — Range —
Q3 2019
Shares 140,421 Value ($000) $3,482 Avg Close — Range —
Q2 2019
Shares 148,900 Value ($000) $3,276 Avg Close — Range —
Q1 2019
Shares 62,493 Value ($000) $1,011 Avg Close — Range —
Q4 2018
Shares 16,130 Value ($000) $237 Avg Close — Range —
Q3 2018
Shares 62,613 Value ($000) $983 Avg Close — Range —