HORIZON PHARMA PLC

CUSIP: G4617B105 Class: SHS

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 1,137,753 Value ($000) $30,071 Avg Close — Range —
Q4 2018
Shares 1,763,588 Value ($000) $34,461 Avg Close — Range —
Q3 2018
Shares 957,818 Value ($000) $18,754 Avg Close — Range —
Q1 2018
Shares 359,593 Value ($000) $5,106 Avg Close — Range —
Q4 2017
Shares 509,788 Value ($000) $7,443 Avg Close — Range —
Q1 2017
Shares 58,397 Value ($000) $863 Avg Close — Range —
Q4 2016
Shares 19,151 Value ($000) $310 Avg Close — Range —
Q4 2015
Shares 186,349 Value ($000) $4,038 Avg Close — Range —
Q2 2015
Shares 110,755 Value ($000) $3,848 Avg Close — Range —
Q1 2015
Shares 278,330 Value ($000) $7,228 Avg Close — Range —