HORIZON PHARMA PLC

CUSIP: G4617B105 Class: SHS

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 1,071,729 Value ($000) $28,326 Avg Close — Range —
Q4 2018
Shares 1,087,129 Value ($000) $21,243 Avg Close — Range —
Q3 2018
Shares 543,029 Value ($000) $10,633 Avg Close — Range —
Q2 2018
Shares 361,729 Value ($000) $5,990 Avg Close — Range —
Q1 2018
Shares 167,929 Value ($000) $2,385 Avg Close — Range —
Q4 2017
Shares 46,029 Value ($000) $672 Avg Close — Range —
Q1 2017
Shares 19,629 Value ($000) $290 Avg Close — Range —
Q4 2015
Shares 16,429 Value ($000) $356 Avg Close — Range —
Q1 2015
Shares 33,400 Value ($000) $867 Avg Close — Range —