ITERUM THERAPEUTICS PLC

CUSIP: G6333L101 Class: Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2021
Shares 528,553 Value ($000) $1,221 Avg Close — Range —
Q1 2021
Shares 430,373 Value ($000) $607 Avg Close — Range —
Q3 2020
Shares 73,146 Value ($000) $77 Avg Close — Range —
Q2 2020
Shares 63,191 Value ($000) $75 Avg Close — Range —