ITERUM THERAPEUTICS PLC

CUSIP: G6333L101 Class: Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2021
Shares 82,664 Value ($000) $32 Avg Close — Range —
Q1 2021
Shares 35,108 Value ($000) $50 Avg Close — Range —