ITERUM THERAPEUTICS PLC

CUSIP: G6333L101 Class: Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2021
Shares 14,300 Value ($000) $6 Avg Close — Range —
Q3 2021
Shares 14,800 Value ($000) $8 Avg Close — Range —
Q1 2021
Shares 198,800 Value ($000) $280 Avg Close — Range —