ITERUM THERAPEUTICS PLC

Ticker: ITRM CUSIP: G6333L200 Class: SHS NEW

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 289,410 Value ($000) $97 Avg Close $0.54 Range $0.26 - $0.83

Q3 2025

Shares 14,518 Value ($000) $10 Avg Close $0.78 Range $0.61 - $1.28

Q2 2025

Shares 92,943 Value ($000) $92 Avg Close $1.04 Range $0.88 - $1.42

Q4 2024

Shares 10,262 Value ($000) $18 Avg Close $1.57 Range $0.81 - $3.02

Q3 2022

Shares 30,479 Value ($000) $49 Avg Close $3.03 Range $1.58 - $7.02

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	289,410	$97	$0.54	$0.26 - $0.83
Q3 2025	14,518	$10	$0.78	$0.61 - $1.28
Q2 2025	92,943	$92	$1.04	$0.88 - $1.42
Q4 2024	10,262	$18	$1.57	$0.81 - $3.02
Q3 2022	30,479	$49	$3.03	$1.58 - $7.02