PROTHENA CORP PLC

Ticker: PRTA CUSIP: G72800108 Class: Common Stock

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q1 2014

Shares 230,142 Value ($000) $8,817 Avg Close $32.24 Range $24.42 - $49.24

Q4 2013

Shares 336,918 Value ($000) $8,935 Avg Close $25.08 Range $18.93 - $30.55

Q3 2013

Shares 369,650 Value ($000) $7,478 Avg Close $17.69 Range $12.14 - $22.48

Q2 2013

Shares 369,650 Value ($000) $4,772 Avg Close $9.30 Range $6.49 - $14.00

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2014	230,142	$8,817	$32.24	$24.42 - $49.24
Q4 2013	336,918	$8,935	$25.08	$18.93 - $30.55
Q3 2013	369,650	$7,478	$17.69	$12.14 - $22.48
Q2 2013	369,650	$4,772	$9.30	$6.49 - $14.00