STRONGBRIDGE BIOPHARMA PLC

CUSIP: G85347105 Class: SHS USD

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2021
Shares 16,300 Value ($000) $48 Avg Close — Range —
Q1 2021
Shares 59,400 Value ($000) $164 Avg Close — Range —
Q4 2020
Shares 333,141 Value ($000) $810 Avg Close — Range —
Q3 2020
Shares 441,452 Value ($000) $927 Avg Close — Range —
Q2 2020
Shares 68,082 Value ($000) $257 Avg Close — Range —
Q1 2020
Shares 78,047 Value ($000) $148 Avg Close — Range —
Q4 2018
Shares 40,590 Value ($000) $182 Avg Close — Range —
Q3 2018
Shares 217,381 Value ($000) $1,054 Avg Close — Range —
Q1 2018
Shares 14,700 Value ($000) $130 Avg Close — Range —