STRONGBRIDGE BIOPHARMA PLC

CUSIP: G85347105 Class: SHS USD

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016

Shares 2,279,099 Value ($000) $5,470 Avg Close — Range —

Q3 2016

Shares 2,501,667 Value ($000) $13,059 Avg Close — Range —

Q2 2016

Shares 2,675,338 Value ($000) $10,648 Avg Close — Range —

Q1 2016

Shares 2,690,702 Value ($000) $12,270 Avg Close — Range —

Q4 2015

Shares 2,690,702 Value ($000) $20,449 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2016	2,279,099	$5,470	—	—
Q3 2016	2,501,667	$13,059	—	—
Q2 2016	2,675,338	$10,648	—	—
Q1 2016	2,690,702	$12,270	—	—
Q4 2015	2,690,702	$20,449	—	—