TIZIANA LIFE SCIENCES LTD

Ticker: TLSA CUSIP: G88912103 Class: COMMON SHARES

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 17,458 Value ($000) $28 Avg Close $1.34 Range $0.73 - $1.81

Q1 2025

Shares 20,392 Value ($000) $22 Avg Close $0.98 Range $0.63 - $1.91

Q4 2023

Shares 11,349 Value ($000) $6 Avg Close $0.63 Range $0.51 - $0.94

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	17,458	$28	$1.34	$0.73 - $1.81
Q1 2025	20,392	$22	$0.98	$0.63 - $1.91
Q4 2023	11,349	$6	$0.63	$0.51 - $0.94