PAINREFORM LTD

CUSIP: M77798144 Class: COM

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 21,344 Value ($000) $14 Avg Close — Range —
Q3 2025
Shares 16,186 Value ($000) $23 Avg Close — Range —