EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 17, 2026

Total Value: $2.204B (100.0% shares, 0.0% debt)

Holdings (30)

ZYME ZYMEWORKS INC 27.4%

Value $605M Shares 22,970,388 Est. Cost $9.83 Unrealized +121.8%

ANAB ANAPTYSBIO INC 17.3%

Value $382M Shares 7,880,094 Est. Cost $23.54 Unrealized +65.6%

JAZZ JAZZ PHARMACEUTICALS PLC 13.2%

Value $290M Shares 1,706,469 Est. Cost $120.72 Unrealized +27.0%

CRNX CRINETICS PHARMACEUTICALS IN 9.1%

Value $200M Shares 4,288,120 Est. Cost $32.41 Unrealized +37.4%

CNTA CENTESSA PHARMACEUTICALS PLC 3.5%

Value $77.91M Shares 3,115,000 Est. Cost $24.88 Unrealized —

CRSP CRISPR THERAPEUTICS AG 3.3%

Value $72.85M Shares 1,389,276 Est. Cost $71.59 Unrealized -16.3%

MBX MBX BIOSCIENCES INC 3.0%

Value $66.98M Shares 2,123,604 Est. Cost $18.46 Unrealized +31.5%

IMNM IMMUNOME INC 2.8%

Value $61.34M Shares 2,855,590 Est. Cost $8.38 Unrealized +109.5%

ORIC ORIC PHARMACEUTICALS INC 2.5%

Value $55.04M Shares 6,728,116 Est. Cost $15.26 Unrealized -24.6%

GLPG GALAPAGOS NV 2.5%

Value $54.51M Shares 1,667,119 Est. Cost $32.49 Unrealized —

XNCR XENCOR INC 2.3%

Value $49.77M Shares 3,251,112 Est. Cost $32.11 Unrealized -53.5%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 1.6%

Value $35.35M Shares 2,823,126 Est. Cost $11.58 Unrealized —

ETON ETON PHARMACEUTICALS INC 1.6%

Value $34.34M Shares 2,030,544 Est. Cost $9.01 Unrealized +95.2%

CGON CG ONCOLOGY INC 1.5%

Value $32.05M Shares 772,000 Est. Cost $41.38 Unrealized 0.0%

ZBIO ZENAS BIOPHARMA INC 1.3%

Value $28.67M Shares 789,500 Est. Cost $32.89 Unrealized 0.0%

NGNE NEUROGENE INC 1.2%

Value $26.19M Shares 1,271,342 Est. Cost $14.32 Unrealized +73.8%

GPCR STRUCTURE THERAPEUTICS INC 1.1%

Value $23.26M Shares 334,380 Est. Cost $69.55 Unrealized —

PCVX VAXCYTE INC 0.9%

Value $20.76M Shares 450,000 Est. Cost $44.73 Unrealized 0.0%

AQST AQUESTIVE THERAPEUTICS INC 0.8%

Value $16.96M Shares 2,625,000 Est. Cost $4.32 Unrealized +44.1%

VYGR VOYAGER THERAPEUTICS INC 0.7%

Value $15.73M Shares 4,002,847 Est. Cost $3.88 Unrealized —

CGON CG ONCOLOGY INC 0.6%

Value $12.16M Shares 292,800 Est. Cost $41.38 Unrealized 0.0%

ATRA ATARA BIOTHERAPEUTICS INC 0.5%

Value $10.37M Shares 573,183 Est. Cost $13.39 Unrealized +11.5%

MNKD MANNKIND CORP 0.4%

Value $9.412M Shares 1,660,000 Est. Cost $5.51 Unrealized 0.0%

— NUVATION BIO INC 0.4%

Value $8.631M Shares 963,333 Est. Cost $10.45 Unrealized —

EOLS EVOLUS INC 0.2%

Value $4.489M Shares 675,000 Est. Cost $6.77 Unrealized 0.0%

IBIO IBIO INC 0.2%

Value $4.3M Shares 2,228,000 Est. Cost $1.36 Unrealized 0.0%

MREO MEREO BIOPHARMA GROUP PLC 0.1%

Value $3.274M Shares 7,856,466 Est. Cost $0.42 Unrealized —

CAMP CAMP4 THERAPEUTICS CORP 0.1%

Value $1.992M Shares 325,000 Est. Cost $4.25 Unrealized 0.0%

XNCR XENCOR INC 0.0%

Value $1.033M Shares 67,500 Est. Cost $32.11 Unrealized -53.5%

SRZNW SURROZEN INC 0.0%

Value $100K Shares 4,444 Est. Cost $7.07 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ZYME	ZYMEWORKS INC	22,970,388	$605M	27.4%	$9.83	+121.8%	COM	98985Y108
ANAB	ANAPTYSBIO INC	7,880,094	$382M	17.3%	$23.54	+65.6%	COM	032724106
JAZZ	JAZZ PHARMACEUTICALS PLC	1,706,469	$290M	13.2%	$120.72	+27.0%	SHS USD	G50871105
CRNX	CRINETICS PHARMACEUTICALS IN	4,288,120	$200M	9.1%	$32.41	+37.4%	COM	22663K107
CNTA	CENTESSA PHARMACEUTICALS PLC	3,115,000	$77.91M	3.5%	$24.88	—	SPONSORED ADS	152309100
CRSP	CRISPR THERAPEUTICS AG	1,389,276	$72.85M	3.3%	$71.59	-16.3%	NAMEN AKT	H17182108
MBX	MBX BIOSCIENCES INC	2,123,604	$66.98M	3.0%	$18.46	+31.5%	COM	55287L101
IMNM	IMMUNOME INC	2,855,590	$61.34M	2.8%	$8.38	+109.5%	COM	45257U108
ORIC	ORIC PHARMACEUTICALS INC	6,728,116	$55.04M	2.5%	$15.26	-24.6%	COM	68622P109
GLPG	GALAPAGOS NV	1,667,119	$54.51M	2.5%	$32.49	—	SPON ADR	36315X101
XNCR	XENCOR INC	3,251,112	$49.77M	2.3%	$32.11	-53.5%	COM	98401F105
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	2,823,126	$35.35M	1.6%	$11.58	—	COM NEW	107924102
ETON	ETON PHARMACEUTICALS INC	2,030,544	$34.34M	1.6%	$9.01	+95.2%	COM	29772L108
CGON	CG ONCOLOGY INC	772,000	$32.05M	1.5%	$41.38	0.0%	COM	156944100
ZBIO	ZENAS BIOPHARMA INC	789,500	$28.67M	1.3%	$32.89	0.0%	COM	98937L105
NGNE	NEUROGENE INC	1,271,342	$26.19M	1.2%	$14.32	+73.8%	COM	64135M105
GPCR	STRUCTURE THERAPEUTICS INC	334,380	$23.26M	1.1%	$69.55	—	SPONSORED ADS	86366E106
PCVX	VAXCYTE INC	450,000	$20.76M	0.9%	$44.73	0.0%	COM	92243G108
AQST	AQUESTIVE THERAPEUTICS INC	2,625,000	$16.96M	0.8%	$4.32	+44.1%	COM	03843E104
VYGR	VOYAGER THERAPEUTICS INC	4,002,847	$15.73M	0.7%	$3.88	—	COM	92915B106
CGON	CG ONCOLOGY INC	292,800	$12.16M	0.6%	$41.38	0.0%	Call	156944100
ATRA	ATARA BIOTHERAPEUTICS INC	573,183	$10.37M	0.5%	$13.39	+11.5%	COM NEW	046513206
MNKD	MANNKIND CORP	1,660,000	$9.412M	0.4%	$5.51	0.0%	COM NEW	56400P706
—	NUVATION BIO INC	963,333	$8.631M	0.4%	$10.45	—	*W EXP 02/10/202	67080N119
EOLS	EVOLUS INC	675,000	$4.489M	0.2%	$6.77	0.0%	COM	30052C107
IBIO	IBIO INC	2,228,000	$4.3M	0.2%	$1.36	0.0%	COM NEW	451033708
MREO	MEREO BIOPHARMA GROUP PLC	7,856,466	$3.274M	0.1%	$0.42	—	SPON ADS	589492107
CAMP	CAMP4 THERAPEUTICS CORP	325,000	$1.992M	0.1%	$4.25	0.0%	COM	13463J101
XNCR	XENCOR INC	67,500	$1.033M	0.0%	$32.11	-53.5%	Call	98401F105
SRZNW	SURROZEN INC	4,444	$100K	0.0%	$7.07	—	*W EXP 08/01/203	86889P117