EcoR1 Capital, LLC Quant / Systematic

Location: San Francisco, CA

CIK: 0001587114 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value: $2.084B (100.0% shares, 0.0% debt)

Holdings (30)

ZYME ZYMEWORKS INC 18.8%

Value $392M Shares 22,970,388 Est. Cost $9.83 Unrealized +45.6%

ANAB ANAPTYSBIO INC 11.6%

Value $241M Shares 7,880,094 Est. Cost $23.54 Unrealized -2.5%

QURE UNIQURE NV 11.2%

Value $233M Shares 3,988,971 Est. Cost $9.43 Unrealized +92.6%

JAZZ JAZZ PHARMACEUTICALS PLC 10.8%

Value $225M Shares 1,706,469 Est. Cost $120.72 Unrealized -0.6%

CRNX CRINETICS PHARMACEUTICALS IN 8.6%

Value $179M Shares 4,288,120 Est. Cost $32.41 Unrealized -1.3%

CRSP CRISPR THERAPEUTICS AG 4.3%

Value $90.04M Shares 1,389,276 Est. Cost $71.59 Unrealized -19.8%

TNGX TANGO THERAPEUTICS INC 4.3%

Value $89.3M Shares 10,630,736 Est. Cost $7.06 Unrealized -4.1%

ORIC ORIC PHARMACEUTICALS INC 3.9%

Value $80.74M Shares 6,728,116 Est. Cost $15.26 Unrealized -31.1%

APLS APELLIS PHARMACEUTICALS INC 3.7%

Value $78.01M Shares 3,447,156 Est. Cost $43.04 Unrealized -45.8%

XNCR XENCOR INC 3.5%

Value $72.08M Shares 6,144,767 Est. Cost $32.11 Unrealized -73.0%

GLPG GALAPAGOS NV 2.8%

Value $57.75M Shares 1,667,119 Est. Cost $32.49 Unrealized —

IMNM IMMUNOME INC 2.3%

Value $47.77M Shares 4,079,415 Est. Cost $8.38 Unrealized +18.8%

ETON ETON PHARMACEUTICALS INC 2.1%

Value $44.12M Shares 2,030,544 Est. Cost $9.01 Unrealized +84.1%

MBX MBX BIOSCIENCES INC 1.8%

Value $37.16M Shares 2,123,604 Est. Cost $18.46 Unrealized -27.6%

MDGL MADRIGAL PHARMACEUTICALS INC 1.7%

Value $34.4M Shares 75,000 Est. Cost $235.62 Unrealized +58.3%

RNAM AVIDITY BIOSCIENCES INC 1.6%

Value $33.33M Shares 765,000 Est. Cost $24.25 Unrealized +66.7%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 1.6%

Value $32.69M Shares 2,823,126 Est. Cost $11.58 Unrealized —

NGNE NEUROGENE INC 1.1%

Value $22.03M Shares 1,271,342 Est. Cost $14.32 Unrealized +40.2%

ALKS ALKERMES PLC 0.7%

Value $15M Shares 500,000 Est. Cost $29.76 Unrealized -5.3%

AQST AQUESTIVE THERAPEUTICS INC 0.7%

Value $14.67M Shares 2,625,000 Est. Cost $4.32 Unrealized 0.0%

— METSERA INC 0.7%

Value $14.21M Shares 271,529 Est. Cost $28.22 Unrealized —

CNTA CENTESSA PHARMACEUTICALS PLC 0.6%

Value $13.34M Shares 550,000 Est. Cost $24.25 Unrealized —

PRME PRIME MEDICINE INC 0.4%

Value $8.55M Shares 1,543,326 Est. Cost $4.06 Unrealized 0.0%

ATRA ATARA BIOTHERAPEUTICS INC 0.4%

Value $8.214M Shares 573,183 Est. Cost $13.39 Unrealized -14.0%

KURA KURA ONCOLOGY INC 0.4%

Value $7.722M Shares 872,500 Est. Cost $14.07 Unrealized -49.3%

PEPG PEPGEN INC 0.2%

Value $3.696M Shares 800,000 Est. Cost $1.61 Unrealized 0.0%

— NUVATION BIO INC 0.2%

Value $3.564M Shares 963,333 Est. Cost $10.45 Unrealized —

VYGR VOYAGER THERAPEUTICS INC 0.2%

Value $3.13M Shares 670,303 Est. Cost $3.61 Unrealized —

CMPS COMPASS PATHWAYS PLC 0.1%

Value $1.519M Shares 265,137 Est. Cost $5.73 Unrealized —

SRZNW SURROZEN INC 0.0%

Value $859K Shares 66,665 Est. Cost $7.07 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ZYME	ZYMEWORKS INC	22,970,388	$392M	18.8%	$9.83	+45.6%	COM	98985Y108
ANAB	ANAPTYSBIO INC	7,880,094	$241M	11.6%	$23.54	-2.5%	COM	032724106
QURE	UNIQURE NV	3,988,971	$233M	11.2%	$9.43	+92.6%	SHS	N90064101
JAZZ	JAZZ PHARMACEUTICALS PLC	1,706,469	$225M	10.8%	$120.72	-0.6%	SHS USD	G50871105
CRNX	CRINETICS PHARMACEUTICALS IN	4,288,120	$179M	8.6%	$32.41	-1.3%	COM	22663K107
CRSP	CRISPR THERAPEUTICS AG	1,389,276	$90.04M	4.3%	$71.59	-19.8%	NAMEN AKT	H17182108
TNGX	TANGO THERAPEUTICS INC	10,630,736	$89.3M	4.3%	$7.06	-4.1%	COM	87583X109
ORIC	ORIC PHARMACEUTICALS INC	6,728,116	$80.74M	3.9%	$15.26	-31.1%	COM	68622P109
APLS	APELLIS PHARMACEUTICALS INC	3,447,156	$78.01M	3.7%	$43.04	-45.8%	COM	03753U106
XNCR	XENCOR INC	6,144,767	$72.08M	3.5%	$32.11	-73.0%	COM	98401F105
GLPG	GALAPAGOS NV	1,667,119	$57.75M	2.8%	$32.49	—	SPON ADR	36315X101
IMNM	IMMUNOME INC	4,079,415	$47.77M	2.3%	$8.38	+18.8%	COM	45257U108
ETON	ETON PHARMACEUTICALS INC	2,030,544	$44.12M	2.1%	$9.01	+84.1%	COM	29772L108
MBX	MBX BIOSCIENCES INC	2,123,604	$37.16M	1.8%	$18.46	-27.6%	COM	55287L101
MDGL	MADRIGAL PHARMACEUTICALS INC	75,000	$34.4M	1.7%	$235.62	+58.3%	COM	558868105
RNAM	AVIDITY BIOSCIENCES INC	765,000	$33.33M	1.6%	$24.25	+66.7%	COM	05370A108
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	2,823,126	$32.69M	1.6%	$11.58	—	COM NEW ADDED	107924102
NGNE	NEUROGENE INC	1,271,342	$22.03M	1.1%	$14.32	+40.2%	COM	64135M105
ALKS	ALKERMES PLC	500,000	$15M	0.7%	$29.76	-5.3%	SHS	G01767105
AQST	AQUESTIVE THERAPEUTICS INC	2,625,000	$14.67M	0.7%	$4.32	0.0%	COM	03843E104
—	METSERA INC	271,529	$14.21M	0.7%	$28.22	—	COM	59267L107
CNTA	CENTESSA PHARMACEUTICALS PLC	550,000	$13.34M	0.6%	$24.25	—	SPONSORED ADS	152309100
PRME	PRIME MEDICINE INC	1,543,326	$8.55M	0.4%	$4.06	0.0%	COM	74168J101
ATRA	ATARA BIOTHERAPEUTICS INC	573,183	$8.214M	0.4%	$13.39	-14.0%	COM NEW	046513206
KURA	KURA ONCOLOGY INC	872,500	$7.722M	0.4%	$14.07	-49.3%	COM	50127T109
PEPG	PEPGEN INC	800,000	$3.696M	0.2%	$1.61	0.0%	COM	713317105
—	NUVATION BIO INC	963,333	$3.564M	0.2%	$10.45	—	*W EXP 02/10/202	67080N119
VYGR	VOYAGER THERAPEUTICS INC	670,303	$3.13M	0.2%	$3.61	—	COM	92915B106
CMPS	COMPASS PATHWAYS PLC	265,137	$1.519M	0.1%	$5.73	—	SPONSORED ADS	20451W101
SRZNW	SURROZEN INC	66,665	$859K	0.0%	$7.07	—	*W EXP 08/01/203	86889P117