SR ONE CAPITAL MANAGEMENT, LP Long-Term Concentrated

Location: Redwood City, CA

CIK: 0001910264 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value: $461M (100.0% shares, 0.0% debt)

Holdings (13)

ACLX Arcellx, Inc. 33.5%

Value $155M Shares 2,346,630 Est. Cost $16.72 Unrealized +272.4%

SPRY ARS Pharmaceuticals, Inc. 15.2%

Value $70.03M Shares 4,012,903 Est. Cost $6.79 Unrealized +112.6%

CRSP CRISPR Therapeutics AG 11.1%

Value $51.02M Shares 1,048,951 Est. Cost $71.59 Unrealized -45.9%

ZBIO Zenas BioPharma, Inc 10.3%

Value $47.59M Shares 4,911,539 Est. Cost $17.98 Unrealized -45.8%

ORIC ORIC Pharmaceuticals, Inc. 9.9%

Value $45.83M Shares 4,514,929 Est. Cost $6.71 Unrealized 0.0%

MLYS Mineralys Therapeutics Inc. 9.2%

Value $42.32M Shares 3,127,933 Est. Cost $14.62 Unrealized -0.9%

DSGN Design Therapeutics, Inc. 4.8%

Value $21.99M Shares 6,526,476 Est. Cost $16.67 Unrealized -77.6%

OCS Oculis Holding AG 1.4%

Value $6.26M Shares 322,500 Est. Cost $20.50 Unrealized -10.4%

ALMS Alumis Inc. 1.3%

Value $5.88M Shares 1,959,896 Est. Cost $13.30 Unrealized -64.5%

NKTX Nkarta, Inc. 1.2%

Value $5.533M Shares 3,333,333 Est. Cost $11.49 Unrealized -84.1%

ORKA Oruka Therapeutics, Inc 1.0%

Value $4.824M Shares 430,330 Est. Cost $33.46 Unrealized -68.9%

KALA KALA Bio, Inc. 0.6%

Value $2.851M Shares 598,940 Est. Cost $6.53 Unrealized -40.2%

ENGN enGene Holdings Inc. 0.6%

Value $2.722M Shares 747,750 Est. Cost $11.04 Unrealized -66.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ACLX	Arcellx, Inc.	2,346,630	$155M	33.5%	$16.72	+272.4%	Common Stock	03940C100
SPRY	ARS Pharmaceuticals, Inc.	4,012,903	$70.03M	15.2%	$6.79	+112.6%	Common Stock	82835W108
CRSP	CRISPR Therapeutics AG	1,048,951	$51.02M	11.1%	$71.59	-45.9%	Common Shares	H17182108
ZBIO	Zenas BioPharma, Inc	4,911,539	$47.59M	10.3%	$17.98	-45.8%	Common Stock	98937L105
ORIC	ORIC Pharmaceuticals, Inc.	4,514,929	$45.83M	9.9%	$6.71	0.0%	Common Stock	68622P109
MLYS	Mineralys Therapeutics Inc.	3,127,933	$42.32M	9.2%	$14.62	-0.9%	Common Stock	603170101
DSGN	Design Therapeutics, Inc.	6,526,476	$21.99M	4.8%	$16.67	-77.6%	Common Stock	25056L103
OCS	Oculis Holding AG	322,500	$6.26M	1.4%	$20.50	-10.4%	Ordinary Shares	H5870P102
ALMS	Alumis Inc.	1,959,896	$5.88M	1.3%	$13.30	-64.5%	Common Stock	022307102
NKTX	Nkarta, Inc.	3,333,333	$5.533M	1.2%	$11.49	-84.1%	Common Stock	65487U108
ORKA	Oruka Therapeutics, Inc	430,330	$4.824M	1.0%	$33.46	-68.9%	Common Stock	687604108
KALA	KALA Bio, Inc.	598,940	$2.851M	0.6%	$6.53	-40.2%	Common Stock	483119202
ENGN	enGene Holdings Inc.	747,750	$2.722M	0.6%	$11.04	-66.0%	Common Shares	29286M105