SR ONE CAPITAL MANAGEMENT, LP Long-Term Concentrated

Location: Redwood City, CA

CIK: 0001910264 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 12, 2025

Total Value: $691M (100.0% shares, 0.0% debt)

Holdings (12)

ACLX Arcellx, Inc. 27.9%

Value $193M Shares 2,346,630 Est. Cost $16.72 Unrealized +330.6%

CRSP CRISPR Therapeutics AG 19.1%

Value $132M Shares 2,038,763 Est. Cost $64.71 Unrealized -11.3%

ZBIO Zenas BioPharma, Inc 15.8%

Value $109M Shares 4,911,539 Est. Cost $17.98 Unrealized -9.5%

MLYS Mineralys Therapeutics Inc. 11.6%

Value $80.16M Shares 2,113,933 Est. Cost $14.62 Unrealized +47.9%

ORIC ORIC Pharmaceuticals, Inc. 7.8%

Value $54.18M Shares 4,514,929 Est. Cost $6.71 Unrealized +56.7%

DSGN Design Therapeutics, Inc. 7.1%

Value $49.14M Shares 6,526,476 Est. Cost $16.67 Unrealized -70.0%

SPRY ARS Pharmaceuticals, Inc. 5.8%

Value $40.33M Shares 4,012,903 Est. Cost $6.79 Unrealized +111.5%

ORKA Oruka Therapeutics, Inc 1.2%

Value $8.275M Shares 430,330 Est. Cost $33.46 Unrealized -55.7%

ALMS Alumis Inc. 1.1%

Value $7.82M Shares 1,959,896 Est. Cost $13.30 Unrealized -69.0%

NKTX Nkarta, Inc. 1.0%

Value $6.9M Shares 3,333,333 Est. Cost $11.49 Unrealized -82.1%

OCS Oculis Holding AG 0.8%

Value $5.67M Shares 322,500 Est. Cost $20.50 Unrealized -13.5%

ENGN enGene Holdings Inc. 0.7%

Value $5.107M Shares 747,750 Est. Cost $11.04 Unrealized -58.7%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ACLX	Arcellx, Inc.	2,346,630	$193M	27.9%	$16.72	+330.6%	Common Stock	03940C100
CRSP	CRISPR Therapeutics AG	2,038,763	$132M	19.1%	$64.71	-11.3%	Common Shares	H17182108
ZBIO	Zenas BioPharma, Inc	4,911,539	$109M	15.8%	$17.98	-9.5%	Common Stock	98937L105
MLYS	Mineralys Therapeutics Inc.	2,113,933	$80.16M	11.6%	$14.62	+47.9%	Common Stock	603170101
ORIC	ORIC Pharmaceuticals, Inc.	4,514,929	$54.18M	7.8%	$6.71	+56.7%	Common Stock	68622P109
DSGN	Design Therapeutics, Inc.	6,526,476	$49.14M	7.1%	$16.67	-70.0%	Common Stock	25056L103
SPRY	ARS Pharmaceuticals, Inc.	4,012,903	$40.33M	5.8%	$6.79	+111.5%	Common Stock	82835W108
ORKA	Oruka Therapeutics, Inc	430,330	$8.275M	1.2%	$33.46	-55.7%	Common Stock	687604108
ALMS	Alumis Inc.	1,959,896	$7.82M	1.1%	$13.30	-69.0%	Common Stock	022307102
NKTX	Nkarta, Inc.	3,333,333	$6.9M	1.0%	$11.49	-82.1%	Common Stock	65487U108
OCS	Oculis Holding AG	322,500	$5.67M	0.8%	$20.50	-13.5%	Ordinary Shares	H5870P102
ENGN	enGene Holdings Inc.	747,750	$5.107M	0.7%	$11.04	-58.7%	Common Shares	29286M105