SR ONE CAPITAL MANAGEMENT, LP Long-Term Concentrated

Location: Redwood City, CA

CIK: 0001910264 · Show all filings

Period: Q1 2026 (← Previous) (Next →)

Filing Date: May 14, 2026

Total Value: $915M (100.0% shares, 0.0% debt)

Holdings (14)

ACLX Arcellx, Inc. 29.4%

Value $269M Shares 2,346,630 Est. Cost $16.72 Unrealized +326.5%

MANE Veradermics, Inc. 16.6%

Value $152M Shares 2,401,868 Est. Cost $63.15 Unrealized —

ZBIO Zenas BioPharma, Inc 10.8%

Value $98.49M Shares 5,037,854 Est. Cost $18.35 Unrealized +19.2%

CRSP CRISPR Therapeutics AG 10.6%

Value $96.98M Shares 2,038,763 Est. Cost $64.71 Unrealized -17.3%

DSGN Design Therapeutics, Inc. 7.6%

Value $69.44M Shares 6,526,476 Est. Cost $16.67 Unrealized -40.1%

ORIC ORIC Pharmaceuticals, Inc. 6.4%

Value $58.48M Shares 4,514,929 Est. Cost $6.71 Unrealized +60.4%

ALMS Alumis Inc. 4.7%

Value $43.18M Shares 1,959,896 Est. Cost $13.30 Unrealized +82.9%

MLYS Mineralys Therapeutics Inc. 4.6%

Value $42.37M Shares 1,563,966 Est. Cost $14.62 Unrealized +114.5%

SPRY ARS Pharmaceuticals, Inc. 3.5%

Value $32.22M Shares 4,012,903 Est. Cost $6.79 Unrealized +50.8%

ORKA Oruka Therapeutics, Inc 2.3%

Value $21.11M Shares 430,330 Est. Cost $33.46 Unrealized -3.0%

OCS Oculis Holding AG 1.9%

Value $17.04M Shares 641,022 Est. Cost $20.25 Unrealized +30.7%

NKTX Nkarta, Inc. 0.8%

Value $7.033M Shares 3,333,333 Est. Cost $11.49 Unrealized -81.0%

ENGN enGene Holdings Inc. 0.6%

Value $5.092M Shares 747,750 Est. Cost $11.04 Unrealized -12.5%

RARE Ultragenyx Pharmaceutical Inc. 0.3%

Value $2.886M Shares 137,753 Est. Cost $32.88 Unrealized -29.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ACLX	Arcellx, Inc.	2,346,630	$269M	29.4%	$16.72	+326.5%	Common Stock	03940C100
MANE	Veradermics, Inc.	2,401,868	$152M	16.6%	$63.15	—	Common Stock	922967104
ZBIO	Zenas BioPharma, Inc	5,037,854	$98.49M	10.8%	$18.35	+19.2%	Common Stock	98937L105
CRSP	CRISPR Therapeutics AG	2,038,763	$96.98M	10.6%	$64.71	-17.3%	Common Shares	H17182108
DSGN	Design Therapeutics, Inc.	6,526,476	$69.44M	7.6%	$16.67	-40.1%	Common Stock	25056L103
ORIC	ORIC Pharmaceuticals, Inc.	4,514,929	$58.48M	6.4%	$6.71	+60.4%	Common Stock	68622P109
ALMS	Alumis Inc.	1,959,896	$43.18M	4.7%	$13.30	+82.9%	Common Stock	022307102
MLYS	Mineralys Therapeutics Inc.	1,563,966	$42.37M	4.6%	$14.62	+114.5%	Common Stock	603170101
SPRY	ARS Pharmaceuticals, Inc.	4,012,903	$32.22M	3.5%	$6.79	+50.8%	Common Stock	82835W108
ORKA	Oruka Therapeutics, Inc	430,330	$21.11M	2.3%	$33.46	-3.0%	Common Stock	687604108
OCS	Oculis Holding AG	641,022	$17.04M	1.9%	$20.25	+30.7%	Ordinary Shares	H5870P102
NKTX	Nkarta, Inc.	3,333,333	$7.033M	0.8%	$11.49	-81.0%	Common Stock	65487U108
ENGN	enGene Holdings Inc.	747,750	$5.092M	0.6%	$11.04	-12.5%	Common Shares	29286M105
RARE	Ultragenyx Pharmaceutical Inc.	137,753	$2.886M	0.3%	$32.88	-29.0%	Common Stock	90400D108