SR ONE CAPITAL MANAGEMENT, LP Long-Term Concentrated

Location: Redwood City, CA

CIK: 0001910264 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 12, 2026

Total Value: $706M (100.0% shares, 0.0% debt)

Holdings (13)

ZBIO Zenas BioPharma, Inc 25.9%

Value $183M Shares 5,037,854 Est. Cost $18.35 Unrealized +79.2%

ACLX Arcellx, Inc. 21.7%

Value $153M Shares 2,346,630 Est. Cost $16.72 Unrealized +377.1%

CRSP CRISPR Therapeutics AG 15.1%

Value $107M Shares 2,038,763 Est. Cost $64.71 Unrealized -7.4%

DSGN Design Therapeutics, Inc. 8.7%

Value $61.22M Shares 6,526,476 Est. Cost $16.67 Unrealized -53.0%

MLYS Mineralys Therapeutics Inc. 8.0%

Value $56.76M Shares 1,563,966 Est. Cost $14.62 Unrealized +174.3%

SPRY ARS Pharmaceuticals, Inc. 6.6%

Value $46.75M Shares 4,012,903 Est. Cost $6.79 Unrealized +43.3%

ORIC ORIC Pharmaceuticals, Inc. 5.3%

Value $37.75M Shares 4,514,929 Est. Cost $6.71 Unrealized +71.5%

ALMS Alumis Inc. 2.7%

Value $19.13M Shares 1,959,896 Est. Cost $13.30 Unrealized -47.5%

ORKA Oruka Therapeutics, Inc 1.8%

Value $13.04M Shares 430,330 Est. Cost $33.46 Unrealized -16.7%

OCS Oculis Holding AG 1.8%

Value $12.8M Shares 641,022 Est. Cost $20.25 Unrealized -1.2%

ENGN enGene Holdings Inc. 1.0%

Value $6.752M Shares 747,750 Est. Cost $11.04 Unrealized -27.4%

NKTX Nkarta, Inc. 0.9%

Value $6.167M Shares 3,333,333 Est. Cost $11.49 Unrealized -82.6%

RARE Ultragenyx Pharmaceutical Inc. 0.4%

Value $3.168M Shares 137,753 Est. Cost $32.88 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
ZBIO	Zenas BioPharma, Inc	5,037,854	$183M	25.9%	$18.35	+79.2%	Common Stock	98937L105
ACLX	Arcellx, Inc.	2,346,630	$153M	21.7%	$16.72	+377.1%	Common Stock	03940C100
CRSP	CRISPR Therapeutics AG	2,038,763	$107M	15.1%	$64.71	-7.4%	Common Shares	H17182108
DSGN	Design Therapeutics, Inc.	6,526,476	$61.22M	8.7%	$16.67	-53.0%	Common Stock	25056L103
MLYS	Mineralys Therapeutics Inc.	1,563,966	$56.76M	8.0%	$14.62	+174.3%	Common Stock	603170101
SPRY	ARS Pharmaceuticals, Inc.	4,012,903	$46.75M	6.6%	$6.79	+43.3%	Common Stock	82835W108
ORIC	ORIC Pharmaceuticals, Inc.	4,514,929	$37.75M	5.3%	$6.71	+71.5%	Common Stock	68622P109
ALMS	Alumis Inc.	1,959,896	$19.13M	2.7%	$13.30	-47.5%	Common Stock	022307102
ORKA	Oruka Therapeutics, Inc	430,330	$13.04M	1.8%	$33.46	-16.7%	Common Stock	687604108
OCS	Oculis Holding AG	641,022	$12.8M	1.8%	$20.25	-1.2%	Ordinary Shares	H5870P102
ENGN	enGene Holdings Inc.	747,750	$6.752M	1.0%	$11.04	-27.4%	Common Shares	29286M105
NKTX	Nkarta, Inc.	3,333,333	$6.167M	0.9%	$11.49	-82.6%	Common Stock	65487U108
RARE	Ultragenyx Pharmaceutical Inc.	137,753	$3.168M	0.4%	$32.88	0.0%	Common Stock	90400D108