Sio Capital Management, LLC Hedge Fund

Location: New York, NY

CIK: 0001482416 · Show all filings

Period: Q4 2023 (← Previous) (Next →)

Filing Date: Feb 13, 2024

Total Value: $439M (100.0% shares, 0.0% debt)

Holdings (43)

— MIRATI THERAPEUTICS INC 19.4%

Value $85.3M Shares 1,451,925 Est. Cost $58.75 Unrealized —

— GRACELL BIOTECHNOLOGIES INC 11.4%

Value $50.22M Shares 5,001,580 Est. Cost $7.06 Unrealized —

— LABORATORY CORP AMER HLDGS 8.5%

Value $37.53M Shares 165,123 Est. Cost $234.91 Unrealized —

CI THE CIGNA GROUP 7.9%

Value $34.9M Shares 116,553 Est. Cost $254.50 Unrealized +10.3%

GMED GLOBUS MED INC 6.5%

Value $28.36M Shares 532,089 Est. Cost $57.05 Unrealized -14.6%

INSM INSMED INC 6.1%

Value $26.7M Shares 861,700 Est. Cost — Unrealized —

GSK GSK PLC 4.8%

Value $21.18M Shares 571,391 Est. Cost $35.83 Unrealized —

— IMMUNOGEN INC 4.4%

Value $19.11M Shares 644,366 Est. Cost $25.76 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 4.0%

Value $17.6M Shares 80,050 Est. Cost $190.39 Unrealized +21.1%

EMBC EMBECTA CORP 3.2%

Value $13.93M Shares 736,008 Est. Cost $16.48 Unrealized -9.4%

SRPT SAREPTA THERAPEUTICS INC 3.1%

Value $13.63M Shares 141,300 Est. Cost — Unrealized —

PTGX PROTAGONIST THERAPEUTICS INC 2.4%

Value $10.55M Shares 460,044 Est. Cost $18.53 Unrealized -5.6%

TFX TELEFLEX INCORPORATED 2.1%

Value $9.108M Shares 36,527 Est. Cost $222.37 Unrealized -5.6%

ZBH ZIMMER BIOMET HOLDINGS INC 2.0%

Value $8.799M Shares 72,300 Est. Cost $124.17 Unrealized -11.9%

NEOG NEOGEN CORP 2.0%

Value $8.587M Shares 427,000 Est. Cost — Unrealized —

HCSG HEALTHCARE SVCS GROUP INC 1.9%

Value $8.403M Shares 810,307 Est. Cost $12.44 Unrealized -19.8%

SPRY ARS PHARMACEUTICALS INC 1.4%

Value $6.06M Shares 1,105,911 Est. Cost $6.60 Unrealized -33.6%

BBIO BRIDGEBIO PHARMA INC 1.2%

Value $5.319M Shares 131,753 Est. Cost $28.38 Unrealized +5.8%

OCUL OCULAR THERAPEUTIX INC 1.0%

Value $4.333M Shares 971,446 Est. Cost $2.96 Unrealized 0.0%

— MERRIMACK PHARMACEUTICALS IN 0.9%

Value $3.868M Shares 288,466 Est. Cost $11.58 Unrealized —

— HARPOON THERAPEUTICS INC 0.8%

Value $3.388M Shares 297,936 Est. Cost $7.23 Unrealized —

— X4 PHARMACEUTICALS INC 0.7%

Value $3.009M Shares 3,588,427 Est. Cost $1.43 Unrealized —

— FUSION PHARMACEUTICALS INC 0.5%

Value $2.364M Shares 246,036 Est. Cost $11.22 Unrealized —

CMPS COMPASS PATHWAYS PLC 0.5%

Value $2.201M Shares 251,532 Est. Cost $8.75 Unrealized —

ARQT ARCUTIS BIOTHERAPEUTICS INC 0.5%

Value $2.054M Shares 635,969 Est. Cost $9.70 Unrealized -72.0%

IRWD IRONWOOD PHARMACEUTICALS INC 0.4%

Value $1.869M Shares 163,400 Est. Cost — Unrealized —

— THIRD HARMONIC BIO INC 0.4%

Value $1.792M Shares 163,363 Est. Cost $10.97 Unrealized —

PRLD PRELUDE THERAPEUTICS INC 0.3%

Value $1.368M Shares 320,394 Est. Cost $3.75 Unrealized -18.9%

APRE APREA THERAPEUTICS INC 0.3%

Value $1.316M Shares 280,000 Est. Cost $7.27 Unrealized -43.9%

MODD MODULAR MED INC 0.3%

Value $1.255M Shares 689,352 Est. Cost $4.31 Unrealized -70.3%

IDYA IDEAYA BIOSCIENCES INC 0.3%

Value $1.174M Shares 33,007 Est. Cost $13.45 Unrealized +121.8%

NYXH NYXOAH SA 0.2%

Value $928K Shares 200,076 Est. Cost $7.82 Unrealized -29.7%

CRBP CORBUS PHARMACEUTICALS HLDGS 0.2%

Value $906K Shares 150,000 Est. Cost $4.38 Unrealized +22.7%

FHTX FOGHORN THERAPEUTICS INC 0.2%

Value $785K Shares 121,672 Est. Cost $4.31 Unrealized 0.0%

VNDA VANDA PHARMACEUTICALS INC 0.1%

Value $412K Shares 97,616 Est. Cost $11.29 Unrealized -64.3%

INGN INOGEN INC 0.1%

Value $290K Shares 52,794 Est. Cost $31.10 Unrealized -83.0%

RCKTW ROCKET PHARMACEUTICALS INC 0.0%

Value $172K Shares 400,000 Est. Cost $0.16 Unrealized —

— NEXTCURE INC 0.0%

Value $148K Shares 130,000 Est. Cost $6.00 Unrealized —

— ASLAN PHARMACEUTICALS LTD 0.0%

Value $133K Shares 254,150 Est. Cost $2.88 Unrealized —

— VINCERX PHARMA INC 0.0%

Value $120K Shares 102,049 Est. Cost $18.89 Unrealized —

HUMAW HUMACYTE INC 0.0%

Value $21,642 Shares 49,998 Est. Cost $0.60 Unrealized —

— CAREMAX INC 0.0%

Value $15,315 Shares 30,741 Est. Cost $8.24 Unrealized —

— CAREMAX INC 0.0%

Value $175 Shares 12,808 Est. Cost $0.44 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	MIRATI THERAPEUTICS INC	1,451,925	$85.3M	19.4%	$58.75	—	COM	60468T105
—	GRACELL BIOTECHNOLOGIES INC	5,001,580	$50.22M	11.4%	$7.06	—	SPONSORED ADS	38406L103
—	LABORATORY CORP AMER HLDGS	165,123	$37.53M	8.5%	$234.91	—	COM NEW	50540R409
CI	THE CIGNA GROUP	116,553	$34.9M	7.9%	$254.50	+10.3%	COM	125523100
GMED	GLOBUS MED INC	532,089	$28.36M	6.5%	$57.05	-14.6%	CL A	379577208
INSM	INSMED INC	861,700	$26.7M	6.1%	—	—	Put	457669307
GSK	GSK PLC	571,391	$21.18M	4.8%	$35.83	—	SPONSORED ADR	37733W204
—	IMMUNOGEN INC	644,366	$19.11M	4.4%	$25.76	—	COM	45253H101
UTHR	UNITED THERAPEUTICS CORP DEL	80,050	$17.6M	4.0%	$190.39	+21.1%	COM	91307C102
EMBC	EMBECTA CORP	736,008	$13.93M	3.2%	$16.48	-9.4%	COMMON STOCK	29082K105
SRPT	SAREPTA THERAPEUTICS INC	141,300	$13.63M	3.1%	—	—	Put	803607100
PTGX	PROTAGONIST THERAPEUTICS INC	460,044	$10.55M	2.4%	$18.53	-5.6%	COM	74366E102
TFX	TELEFLEX INCORPORATED	36,527	$9.108M	2.1%	$222.37	-5.6%	COM	879369106
ZBH	ZIMMER BIOMET HOLDINGS INC	72,300	$8.799M	2.0%	$124.17	-11.9%	COM	98956P102
NEOG	NEOGEN CORP	427,000	$8.587M	2.0%	—	—	Put	640491106
HCSG	HEALTHCARE SVCS GROUP INC	810,307	$8.403M	1.9%	$12.44	-19.8%	COM	421906108
SPRY	ARS PHARMACEUTICALS INC	1,105,911	$6.06M	1.4%	$6.60	-33.6%	COM	82835W108
BBIO	BRIDGEBIO PHARMA INC	131,753	$5.319M	1.2%	$28.38	+5.8%	COM	10806X102
OCUL	OCULAR THERAPEUTIX INC	971,446	$4.333M	1.0%	$2.96	0.0%	COM	67576A100
—	MERRIMACK PHARMACEUTICALS IN	288,466	$3.868M	0.9%	$11.58	—	COM NEW	590328209
—	HARPOON THERAPEUTICS INC	297,936	$3.388M	0.8%	$7.23	—	COM NEW	41358P205
—	X4 PHARMACEUTICALS INC	3,588,427	$3.009M	0.7%	$1.43	—	COM	98420X103
—	FUSION PHARMACEUTICALS INC	246,036	$2.364M	0.5%	$11.22	—	COM	36118A100
CMPS	COMPASS PATHWAYS PLC	251,532	$2.201M	0.5%	$8.75	—	SPONSORED ADS	20451W101
ARQT	ARCUTIS BIOTHERAPEUTICS INC	635,969	$2.054M	0.5%	$9.70	-72.0%	COM	03969K108
IRWD	IRONWOOD PHARMACEUTICALS INC	163,400	$1.869M	0.4%	—	—	Put	46333X108
—	THIRD HARMONIC BIO INC	163,363	$1.792M	0.4%	$10.97	—	COM	88427A107
PRLD	PRELUDE THERAPEUTICS INC	320,394	$1.368M	0.3%	$3.75	-18.9%	COM	74065P101
APRE	APREA THERAPEUTICS INC	280,000	$1.316M	0.3%	$7.27	-43.9%	COM NEW	03836J201
MODD	MODULAR MED INC	689,352	$1.255M	0.3%	$4.31	-70.3%	COM NEW	60785L207
IDYA	IDEAYA BIOSCIENCES INC	33,007	$1.174M	0.3%	$13.45	+121.8%	COM	45166A102
NYXH	NYXOAH SA	200,076	$928K	0.2%	$7.82	-29.7%	SHS	B6S7WD106
CRBP	CORBUS PHARMACEUTICALS HLDGS	150,000	$906K	0.2%	$4.38	+22.7%	COM NEW	21833P301
FHTX	FOGHORN THERAPEUTICS INC	121,672	$785K	0.2%	$4.31	0.0%	COM	344174107
VNDA	VANDA PHARMACEUTICALS INC	97,616	$412K	0.1%	$11.29	-64.3%	COM	921659108
INGN	INOGEN INC	52,794	$290K	0.1%	$31.10	-83.0%	COM	45780L104
RCKTW	ROCKET PHARMACEUTICALS INC	400,000	$172K	0.0%	$0.16	—	*W EXP 09/02/202	77313F114
—	NEXTCURE INC	130,000	$148K	0.0%	$6.00	—	COM	65343E108
—	ASLAN PHARMACEUTICALS LTD	254,150	$133K	0.0%	$2.88	—	SPON ADS NEW	04522R200
—	VINCERX PHARMA INC	102,049	$120K	0.0%	$18.89	—	COM NEW	92731L106
HUMAW	HUMACYTE INC	49,998	$21,642	0.0%	$0.60	—	*W EXP 08/27/202	44486Q111
—	CAREMAX INC	30,741	$15,315	0.0%	$8.24	—	COM CL A	14171W103
—	CAREMAX INC	12,808	$175	0.0%	$0.44	—	*W EXP 06/08/202	14171W111