ACUTA CAPITAL PARTNERS, LLC Hedge Fund

Location: Redwood City, CA

CIK: 0001582844 · Show all filings

Period: Q4 2019 (← Previous) (Next →)

Filing Date: Feb 14, 2020

Total Value: $404M (100.0% shares, 0.0% debt)

Holdings (38)

AXSM AXSOME THERAPEUTICS INC 15.6%

Value $62.79M Shares 607,500 Est. Cost $23.68 Unrealized +70.6%

XBI SPDR SERIES TRUST 11.8%

Value $47.55M Shares 500,000 Est. Cost — Unrealized —

ARWR ARROWHEAD PHARMACEUTICALS IN 7.0%

Value $28.07M Shares 442,500 Est. Cost $23.72 Unrealized +109.2%

— KADMON HLDGS INC 6.8%

Value $27.36M Shares 6,040,000 Est. Cost $3.68 Unrealized —

AUPH AURINIA PHARMACEUTICALS INC 5.3%

Value $21.43M Shares 1,057,500 Est. Cost $6.93 Unrealized +32.9%

— INTRA CELLULAR THERAPIES INC 5.0%

Value $20.14M Shares 587,089 Est. Cost $34.31 Unrealized —

IOVA IOVANCE BIOTHERAPEUTICS INC 4.5%

Value $18.17M Shares 656,500 Est. Cost $7.92 Unrealized +187.3%

— ADVERUM BIOTECHNOLOGIES INC 3.8%

Value $15.23M Shares 1,322,500 Est. Cost $11.52 Unrealized —

ARVN ARVINAS INC 3.6%

Value $14.63M Shares 356,000 Est. Cost $19.30 Unrealized +51.7%

— AVADEL PHARMACEUTICALS PLC 3.0%

Value $12.27M Shares 1,625,000 Est. Cost $7.55 Unrealized —

XENE XENON PHARMACEUTICALS INC 3.0%

Value $12.03M Shares 917,500 Est. Cost $8.16 Unrealized +29.0%

— KARYOPHARM THERAPEUTICS INC 2.8%

Value $11.31M Shares 590,000 Est. Cost $15.33 Unrealized —

BCRX BIOCRYST PHARMACEUTICALS 2.4%

Value $9.746M Shares 2,825,000 Est. Cost $2.52 Unrealized 0.0%

— CONSTELLATION PHARMCETICLS I 2.3%

Value $9.304M Shares 197,500 Est. Cost $47.11 Unrealized —

— DICERNA PHARMACEUTICALS INC 2.1%

Value $8.537M Shares 387,500 Est. Cost $22.03 Unrealized —

MIST MILESTONE PHARMACEUTICALS IN 2.0%

Value $8.141M Shares 508,500 Est. Cost $19.80 Unrealized -10.3%

— IVERIC BIO INC 1.9%

Value $7.808M Shares 910,000 Est. Cost $8.58 Unrealized —

— REATA PHARMACEUTICALS INC 1.9%

Value $7.768M Shares 38,000 Est. Cost $80.29 Unrealized —

— BELLUS HEALTH INC NEW 1.5%

Value $6.156M Shares 810,000 Est. Cost $6.43 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 1.4%

Value $5.741M Shares 187,500 Est. Cost $27.68 Unrealized 0.0%

— SELECTA BIOSCIENCES INC 1.3%

Value $5.345M Shares 2,364,204 Est. Cost $2.26 Unrealized —

— NEOLEUKIN THERAPEUTICS INC 1.1%

Value $4.589M Shares 372,500 Est. Cost $12.32 Unrealized —

— KARUNA THERAPEUTICS INC 1.0%

Value $4.219M Shares 56,000 Est. Cost $75.34 Unrealized —

— APPLIED THERAPEUTICS INC 1.0%

Value $4.037M Shares 148,000 Est. Cost $18.14 Unrealized —

INSM INSMED INC 1.0%

Value $4.036M Shares 169,000 Est. Cost $26.21 Unrealized -22.4%

— INTRA CELLULAR THERAPIES INC 0.8%

Value $3.431M Shares 100,000 Est. Cost $34.31 Unrealized —

KURA KURA ONCOLOGY INC 0.8%

Value $3.3M Shares 240,000 Est. Cost $16.00 Unrealized -7.4%

— ZYMEWORKS INC 0.8%

Value $3.205M Shares 70,500 Est. Cost $30.08 Unrealized —

— IMMUNOMEDICS INC 0.8%

Value $3.174M Shares 150,000 Est. Cost $21.16 Unrealized —

ASND ASCENDIS PHARMA A S 0.8%

Value $3.13M Shares 22,500 Est. Cost $139.11 Unrealized —

KALV KALVISTA PHARMACEUTICALS INC 0.5%

Value $1.915M Shares 107,500 Est. Cost $13.85 Unrealized -5.8%

— MEDICINES CO 0.5%

Value $1.843M Shares 21,700 Est. Cost $84.93 Unrealized —

QURE UNIQURE NV 0.4%

Value $1.792M Shares 25,000 Est. Cost $54.91 Unrealized 0.0%

— ACASTI PHARMA INC 0.4%

Value $1.519M Shares 620,000 Est. Cost $2.45 Unrealized —

— CHEMOCENTRYX INC 0.3%

Value $1.384M Shares 35,000 Est. Cost $39.54 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.3%

Value $1.152M Shares 100,000 Est. Cost $11.52 Unrealized —

— ZAFGEN INC 0.3%

Value $1.11M Shares 1,000,000 Est. Cost $1.11 Unrealized —

— X4 PHARMACEUTICALS INC 0.1%

Value $428K Shares 40,000 Est. Cost $10.70 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
AXSM	AXSOME THERAPEUTICS INC	607,500	$62.79M	15.6%	$23.68	+70.6%	COM	05464T104
XBI	SPDR SERIES TRUST	500,000	$47.55M	11.8%	—	—	Put	78464A870
ARWR	ARROWHEAD PHARMACEUTICALS IN	442,500	$28.07M	7.0%	$23.72	+109.2%	COM	04280A100
—	KADMON HLDGS INC	6,040,000	$27.36M	6.8%	$3.68	—	COM	48283N106
AUPH	AURINIA PHARMACEUTICALS INC	1,057,500	$21.43M	5.3%	$6.93	+32.9%	COM	05156V102
—	INTRA CELLULAR THERAPIES INC	587,089	$20.14M	5.0%	$34.31	—	COM	46116X101
IOVA	IOVANCE BIOTHERAPEUTICS INC	656,500	$18.17M	4.5%	$7.92	+187.3%	COM	462260100
—	ADVERUM BIOTECHNOLOGIES INC	1,322,500	$15.23M	3.8%	$11.52	—	COM	00773U108
ARVN	ARVINAS INC	356,000	$14.63M	3.6%	$19.30	+51.7%	COM	04335A105
—	AVADEL PHARMACEUTICALS PLC	1,625,000	$12.27M	3.0%	$7.55	—	SPONSORED ADR	05337M104
XENE	XENON PHARMACEUTICALS INC	917,500	$12.03M	3.0%	$8.16	+29.0%	COM	98420N105
—	KARYOPHARM THERAPEUTICS INC	590,000	$11.31M	2.8%	$15.33	—	COM	48576U106
BCRX	BIOCRYST PHARMACEUTICALS	2,825,000	$9.746M	2.4%	$2.52	0.0%	COM	09058V103
—	CONSTELLATION PHARMCETICLS I	197,500	$9.304M	2.3%	$47.11	—	COM	210373106
—	DICERNA PHARMACEUTICALS INC	387,500	$8.537M	2.1%	$22.03	—	COM	253031108
MIST	MILESTONE PHARMACEUTICALS IN	508,500	$8.141M	2.0%	$19.80	-10.3%	COM	59935V107
—	IVERIC BIO INC	910,000	$7.808M	1.9%	$8.58	—	COM	46583P102
—	REATA PHARMACEUTICALS INC	38,000	$7.768M	1.9%	$80.29	—	CL A	75615P103
—	BELLUS HEALTH INC NEW	810,000	$6.156M	1.5%	$6.43	—	COM NEW	07987C204
APLS	APELLIS PHARMACEUTICALS INC	187,500	$5.741M	1.4%	$27.68	0.0%	COM	03753U106
—	SELECTA BIOSCIENCES INC	2,364,204	$5.345M	1.3%	$2.26	—	COM	816212104
—	NEOLEUKIN THERAPEUTICS INC	372,500	$4.589M	1.1%	$12.32	—	COM	64049K104
—	KARUNA THERAPEUTICS INC	56,000	$4.219M	1.0%	$75.34	—	COM	48576A100
—	APPLIED THERAPEUTICS INC	148,000	$4.037M	1.0%	$18.14	—	COM	03828A101
INSM	INSMED INC	169,000	$4.036M	1.0%	$26.21	-22.4%	COM PAR $.01	457669307
—	INTRA CELLULAR THERAPIES INC	100,000	$3.431M	0.8%	$34.31	—	Call	46116X101
KURA	KURA ONCOLOGY INC	240,000	$3.3M	0.8%	$16.00	-7.4%	COM	50127T109
—	ZYMEWORKS INC	70,500	$3.205M	0.8%	$30.08	—	COM	98985W102
—	IMMUNOMEDICS INC	150,000	$3.174M	0.8%	$21.16	—	COM	452907108
ASND	ASCENDIS PHARMA A S	22,500	$3.13M	0.8%	$139.11	—	SPONSORED ADR	04351P101
KALV	KALVISTA PHARMACEUTICALS INC	107,500	$1.915M	0.5%	$13.85	-5.8%	COM	483497103
—	MEDICINES CO	21,700	$1.843M	0.5%	$84.93	—	COM	584688105
QURE	UNIQURE NV	25,000	$1.792M	0.4%	$54.91	0.0%	SHS	N90064101
—	ACASTI PHARMA INC	620,000	$1.519M	0.4%	$2.45	—	CL A NEW	00430K402
—	CHEMOCENTRYX INC	35,000	$1.384M	0.3%	$39.54	—	COM	16383L106
—	ADVERUM BIOTECHNOLOGIES INC	100,000	$1.152M	0.3%	$11.52	—	Call	00773U108
—	ZAFGEN INC	1,000,000	$1.11M	0.3%	$1.11	—	COM	98885E103
—	X4 PHARMACEUTICALS INC	40,000	$428K	0.1%	$10.70	—	COM	98420X103