Location: Greenwich, CT
CIK: 0001856083 · Show all filings
Period: Q3 2025 (← Previous) (Next →)
Filing Date: Nov 14, 2025
Total Value: $3.583B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| GH | GUARDANT HEALTH INC | 4,154,086 | $260M | 7.2% | $29.38 | +85.2% | COM | 40131M109 |
| IONS | IONIS PHARMACEUTICALS INC | 3,808,144 | $249M | 7.0% | $36.01 | +35.6% | COM | 462222100 |
| CYTK | CYTOKINETICS INC | 4,300,000 | $236M | 6.6% | $47.92 | -14.0% | COM NEW | 23282W605 |
| — | AKERO THERAPEUTICS INC | 4,000,978 | $190M | 5.3% | $37.83 | — | COM | 00973Y108 |
| APLS | APELLIS PHARMACEUTICALS INC | 8,000,382 | $181M | 5.1% | $34.58 | -32.6% | COM | 03753U106 |
| TARS | TARSUS PHARMACEUTICALS INC | 3,000,000 | $178M | 5.0% | $48.96 | +0.6% | COM | 87650L103 |
| IMVT | IMMUNOVANT INC | 9,728,845 | $157M | 4.4% | $24.49 | -33.9% | COM | 45258J102 |
| — | DYNAVAX TECHNOLOGIES CORP | 15,726,349 | $156M | 4.4% | $11.53 | — | COM NEW | 268158201 |
| OCUL | OCULAR THERAPEUTIX INC | 11,932,137 | $139M | 3.9% | $4.46 | +168.2% | COM | 67576A100 |
| — | 89BIO INC | 9,356,171 | $138M | 3.8% | $7.72 | — | COM | 282559103 |
| GPCR | STRUCTURE THERAPEUTICS INC | 4,215,811 | $118M | 3.3% | $26.36 | — | SPONSORED ADS | 86366E106 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 5,380,449 | $116M | 3.2% | $18.23 | -1.1% | COM | 92790C104 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,715,691 | $114M | 3.2% | $42.89 | +32.5% | COM | 74366E102 |
| AXSM | AXSOME THERAPEUTICS INC | 900,000 | $109M | 3.1% | $106.63 | +5.6% | COM | 05464T104 |
| PCVX | VAXCYTE INC | 3,000,000 | $108M | 3.0% | $44.67 | -25.8% | COM | 92243G108 |
| MAZE | MAZE THERAPEUTICS INC | 3,948,910 | $102M | 2.9% | $11.76 | +43.6% | COM | 578784100 |
| IMCR | IMMUNOCORE HLDGS PLC | 1,800,000 | $65.39M | 1.8% | $29.99 | — | ADS | 45258D105 |
| BBIO | BRIDGEBIO PHARMA INC | 1,200,000 | $62.33M | 1.7% | $35.75 | +36.4% | COM | 10806X102 |
| GERN | GERON CORP | 41,096,522 | $56.3M | 1.6% | $2.33 | -42.9% | COM | 374163103 |
| TERN | TERNS PHARMACEUTICALS INC | 7,495,000 | $56.29M | 1.6% | $6.22 | +2.7% | COM | 880881107 |
| NRIX | NURIX THERAPEUTICS INC | 6,057,024 | $55.97M | 1.6% | $13.97 | -25.6% | COM | 67080M103 |
| MBX | MBX BIOSCIENCES INC | 3,150,000 | $55.13M | 1.5% | $19.97 | -33.0% | COM | 55287L101 |
| EXAS | EXACT SCIENCES CORP | 1,000,000 | $54.71M | 1.5% | $49.96 | 0.0% | COM | 30063P105 |
| LBRX | LB PHARMACEUTICALS INC | 3,352,804 | $52.94M | 1.5% | $15.87 | 0.0% | COM SHS | 50180M108 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 2,000,000 | $51.74M | 1.4% | $26.06 | -11.1% | COM NEW | 15117B202 |
| ORKA | ORUKA THERAPEUTICS INC | 2,654,781 | $51.05M | 1.4% | $19.06 | -22.2% | COM | 687604108 |
| XENE | XENON PHARMACEUTICALS INC | 1,200,000 | $48.18M | 1.3% | $37.01 | -4.8% | COM | 98420N105 |
| CMPS | COMPASS PATHWAYS PLC | 7,859,648 | $45.04M | 1.3% | $2.86 | — | SPONSORED ADS | 20451W101 |
| ANIP | ANI PHARMACEUTICALS INC | 450,000 | $41.22M | 1.2% | $53.69 | +51.9% | COM | 00182C103 |
| BCAX | BICARA THERAPEUTICS INC | 2,426,657 | $38.32M | 1.1% | $20.79 | -46.1% | COM | 055477103 |
| OLMA | OLEMA PHARMACEUTICALS INC | 3,470,172 | $33.97M | 0.9% | $11.20 | -46.4% | COM | 68062P106 |
| — | CIDARA THERAPEUTICS INC | 300,000 | $28.73M | 0.8% | $56.55 | — | COM NEW | 171757206 |
| QURE | UNIQURE NV | 483,092 | $28.2M | 0.8% | $18.16 | 0.0% | SHS | N90064101 |
| DYN | DYNE THERAPEUTICS INC | 2,000,000 | $25.3M | 0.7% | $11.41 | 0.0% | COM | 26818M108 |
| JBIO | JADE BIOSCIENCES INC | 2,279,892 | $19.68M | 0.5% | $33.31 | -75.5% | COM NEW | 008064206 |
| RAPT | RAPT THERAPEUTICS INC | 751,422 | $19.38M | 0.5% | $7.63 | +71.5% | COM NEW | 75382E208 |
| GHRS | GH RESEARCH PLC | 1,250,000 | $17.88M | 0.5% | $11.18 | +25.1% | ORDINARY SHARES | G3855L106 |
| — | MIND MEDICINE MINDMED INC | 1,500,000 | $17.68M | 0.5% | $8.90 | — | COM NEW | 60255C885 |
| ENGN | ENGENE HOLDINGS INC | 2,239,353 | $15.29M | 0.4% | $9.95 | -54.2% | COM | 29286M105 |
| GMAB | GENMAB A/S | 481,267 | $14.76M | 0.4% | $30.67 | — | SPONSORED ADS | 372303206 |
| TNGX | TANGO THERAPEUTICS INC | 1,454,562 | $12.22M | 0.3% | $6.77 | 0.0% | COM | 87583X109 |
| CNTX | CONTEXT THERAPEUTICS INC | 7,419,355 | $7.188M | 0.2% | $1.72 | -53.0% | COM | 21077P108 |
| IMA | IMAGENEBIO INC | 878,516 | $7.16M | 0.2% | $13.25 | 0.0% | COM | 45175G207 |
| XNCR | XENCOR INC | 549,439 | $6.445M | 0.2% | $18.57 | -53.3% | COM | 98401F105 |
| HELP | CYBIN INC | 1,000,000 | $5.89M | 0.2% | $9.89 | -28.4% | COM NEW | 23256X407 |
| CRMD | CORMEDIX INC | 500,000 | $5.815M | 0.2% | $12.09 | 0.0% | COM | 21900C308 |
| PEPG | PEPGEN INC | 1,200,000 | $5.544M | 0.2% | $1.61 | 0.0% | COM | 713317105 |
| CBIO | CRESCENT BIOPHARMA INC. | 453,686 | $5.394M | 0.2% | $21.15 | -37.3% | COM | G2545C104 |
| ALGS | ALIGOS THERAPEUTICS INC | 444,110 | $4.352M | 0.1% | $16.71 | -45.3% | COM NEW | 01626L204 |
| AUTL | AUTOLUS THERAPEUTICS PLC | 2,568,613 | $4.187M | 0.1% | $2.62 | — | SPON ADS | 05280R100 |
| XFOR | X4 PHARMACEUTICALS INC | 1,122,484 | $3.839M | 0.1% | $2.58 | 0.0% | COM | 98420X202 |
| ACAD | ACADIA PHARMACEUTICALS INC | 105,085 | $2.243M | 0.1% | $23.65 | 0.0% | COM | 004225108 |
| AVTX | AVALO THERAPEUTICS INC | 144,600 | $1.838M | 0.1% | $10.31 | -16.6% | COM NEW | 05338F306 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 24,856 | $1.346M | 0.0% | $57.19 | 0.0% | COM | 09061G101 |
| ZURA | ZURA BIO LTD | 259,014 | $1.122M | 0.0% | $7.12 | -74.7% | CLASS A ORD SHS | G9TY5A101 |
| CLYM | CLIMB BIO INC | 509,789 | $1.025M | 0.0% | $6.66 | -72.1% | COM | 28658R106 |