GREAT POINT PARTNERS LLC Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IRON	DISC MEDICINE INC	250,000	$19,853	6.4%	$84.50	0.0%	COM	254604101
RAPT	RAPT THERAPEUTICS INC	581,187	$19,685	6.4%	$31.06	0.0%	COM NEW	75382E208
VOR	VOR BIOPHARMA INC	1,370,107	$17,921	5.8%	$18.62	0.0%	COM NEW	929033207
KALV	KALVISTA PHARMACEUTICALS INC	685,632	$11,073	3.6%	$13.24	0.0%	COM	483497103
CTNM	CONTINEUM THERAPEUTICS INC	800,000	$9,144	3.0%	$11.41	0.0%	CL A	21217B100
FULC	FULCRUM THERAPEUTICS INC	800,000	$9,048	2.9%	$10.18	0.0%	COM	359616109
RARE	ULTRAGENYX PHARMACEUTICAL IN	300,000	$6,900	2.2%	$32.88	0.0%	COM	90400D108
CGEM	CULLINAN THERAPEUTICS INC	634,032	$6,562	2.1%	$9.02	0.0%	COM	230031106
EVMN	EVOMMUNE INC	325,000	$5,564	1.8%	$18.78	0.0%	COM SHS	30054Y107
SLN	SILENCE THERAPEUTICS PLC	808,032	$4,913	1.6%	$6.08	—	ADS	82686Q101
CLYM	CLIMB BIO INC	979,534	$3,918	1.3%	$2.40	0.0%	COM	28658R106
AVTX	AVALO THERAPEUTICS INC	124,666	$2,264	0.7%	$16.88	0.0%	COM NEW	05338F306

Increased Positions (6)

APGE APOGEE THERAPEUTICS INC 9.2%

Value ($000) $28,230 (+133.7%) Shares 374,000 (+23.0%) Est. Cost $42.82 Unrealized +47.1%

IMVT IMMUNOVANT INC 6.2%

Value ($000) $19,065 (+136.5%) Shares 750,000 (+50.0%) Est. Cost $19.88 Unrealized +12.2%

JBIO JADE BIOSCIENCES INC 4.0%

Value ($000) $12,441 (+127.9%) Shares 806,273 (+27.5%) Est. Cost $24.47 Unrealized -52.1%

DNTH DIANTHUS THERAPEUTICS INC 4.7%

Value ($000) $14,424 (+37.9%) Shares 350,000 (+31.7%) Est. Cost $28.73 Unrealized +34.9%

SLNO SOLENO THERAPEUTICS INC 6.0%

Value ($000) $18,520 (+21.8%) Shares 400,000 (+77.8%) Est. Cost $65.69 Unrealized -16.5%

AMLX AMYLYX PHARMACEUTICALS INC 6.9%

Value ($000) $21,140 (-8.5%) Shares 1,750,000 (+2.9%) Est. Cost $3.96 Unrealized +242.6%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
APGE	APOGEE THERAPEUTICS INC	374,000 (+23.0%)	$28,230 (+133.7%)	9.2%	$42.82	+47.1%	COM	03770N101
IMVT	IMMUNOVANT INC	750,000 (+50.0%)	$19,065 (+136.5%)	6.2%	$19.88	+12.2%	COM	45258J102
JBIO	JADE BIOSCIENCES INC	806,273 (+27.5%)	$12,441 (+127.9%)	4.0%	$24.47	-52.1%	COM NEW	008064206
DNTH	DIANTHUS THERAPEUTICS INC	350,000 (+31.7%)	$14,424 (+37.9%)	4.7%	$28.73	+34.9%	COM	252828108
SLNO	SOLENO THERAPEUTICS INC	400,000 (+77.8%)	$18,520 (+21.8%)	6.0%	$65.69	-16.5%	COM	834203309
AMLX	AMYLYX PHARMACEUTICALS INC	1,750,000 (+2.9%)	$21,140 (-8.5%)	6.9%	$3.96	+242.6%	COM	03237H101

Exited Positions (13)

ASND ASCENDIS PHARMA A/S SPONSORED ADR 4.8%

Value ($000) $14,911 Shares 75,000 Est. Cost $198.81 Unrealized —

ABVX ABIVAX SA SPONSORED ADS 4.1%

Value ($000) $12,735 Shares 150,000 Est. Cost $12.06 Unrealized —

CYTK CYTOKINETICS INC COM NEW 2.7%

Value ($000) $8,244 Shares 150,000 Est. Cost $51.61 Unrealized +20.5%

XENE XENON PHARMACEUTICALS INC 2.6%

Value ($000) $8,030 Shares 200,000 Est. Cost $41.35 Unrealized +1.6%

IONS IONIS PHARMACEUTICALS INC 1.7%

Value ($000) $5,234 Shares 80,000 Est. Cost $35.97 Unrealized +109.3%

— AKERO THERAPEUTICS INC 1.6%

Value ($000) $4,931 Shares 103,848 Est. Cost $53.36 Unrealized —

TSHA TAYSHA GENE THERAPIES INC COM SHS 1.6%

Value ($000) $4,905 Shares 1,500,000 Est. Cost $2.17 Unrealized +123.5%

DBVT DBV TECHNOLOGIES S A SPONSORED ADS 1.2%

Value ($000) $3,786 Shares 378,594 Est. Cost $9.17 Unrealized —

LEGN LEGEND BIOTECH CORP SPONSORED ADS 1.2%

Value ($000) $3,700 Shares 113,460 Est. Cost $34.87 Unrealized —

ABSI ABSCI CORPORATION 0.8%

Value ($000) $2,421 Shares 796,438 Est. Cost $2.76 Unrealized +31.8%

HRMY HRMY 10/17/2025 40 Call 0.8%

Value ($000) $2,343 Shares 85,000 Est. Cost — Unrealized —

PLRX PLIANT THERAPEUTICS INC 0.4%

Value ($000) $1,258 Shares 850,000 Est. Cost $16.18 Unrealized -90.7%

CAPR CAPR 12/19/2025 7.5 Put 0.2%

Value ($000) $632 Shares 87,700 Est. Cost — Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ASND	ASCENDIS PHARMA A/S SPONSORED ADR	75,000	$14,911	4.8%	$198.81	—	—	04351P101
ABVX	ABIVAX SA SPONSORED ADS	150,000	$12,735	4.1%	$12.06	—	—	00370M103
CYTK	CYTOKINETICS INC COM NEW	150,000	$8,244	2.7%	$51.61	+20.5%	—	23282W605
XENE	XENON PHARMACEUTICALS INC	200,000	$8,030	2.6%	$41.35	+1.6%	—	98420N105
IONS	IONIS PHARMACEUTICALS INC	80,000	$5,234	1.7%	$35.97	+109.3%	—	462222100
—	AKERO THERAPEUTICS INC	103,848	$4,931	1.6%	$53.36	—	—	00973Y108
TSHA	TAYSHA GENE THERAPIES INC COM SHS	1,500,000	$4,905	1.6%	$2.17	+123.5%	—	877619106
DBVT	DBV TECHNOLOGIES S A SPONSORED ADS	378,594	$3,786	1.2%	$9.17	—	—	23306J309
LEGN	LEGEND BIOTECH CORP SPONSORED ADS	113,460	$3,700	1.2%	$34.87	—	—	52490G102
ABSI	ABSCI CORPORATION	796,438	$2,421	0.8%	$2.76	+31.8%	—	00091E109
HRMY	HRMY 10/17/2025 40 Call	85,000	$2,343	0.8%	—	—	CALL	413197104
PLRX	PLIANT THERAPEUTICS INC	850,000	$1,258	0.4%	$16.18	-90.7%	—	729139105
CAPR	CAPR 12/19/2025 7.5 Put	87,700	$632	0.2%	—	—	PUT	14070B309

Decreased Positions (4)

RZLT REZOLUTE INC 0.7%

Value ($000) $2,246 (-90.3%) Shares 951,809 (-61.2%) Est. Cost $4.03 Unrealized +94.6%

NKTR NEKTAR THERAPEUTICS 2.9%

Value ($000) $8,910 (-47.8%) Shares 210,732 (-29.8%) Est. Cost $33.10 Unrealized +69.1%

PHVS PHARVARIS N V 0.7%

Value ($000) $2,298 (-40.6%) Shares 82,800 (-46.6%) Est. Cost $22.18 Unrealized +8.6%

NGNE NEUROGENE INC 2.3%

Value ($000) $7,210 (-6.9%) Shares 350,000 (-21.7%) Est. Cost $14.71 Unrealized +69.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RZLT	REZOLUTE INC	951,809 (-61.2%)	$2,246 (-90.3%)	0.7%	$4.03	+94.6%	COM NEW	76200L309
NKTR	NEKTAR THERAPEUTICS	210,732 (-29.8%)	$8,910 (-47.8%)	2.9%	$33.10	+69.1%	COM NEW	640268306
PHVS	PHARVARIS N V	82,800 (-46.6%)	$2,298 (-40.6%)	0.7%	$22.18	+8.6%	COM	N69605108
NGNE	NEUROGENE INC	350,000 (-21.7%)	$7,210 (-6.9%)	2.3%	$14.71	+69.2%	COM	64135M105

Unchanged Positions (7)

ZURA ZURA BIO LTD 6.5%

Value ($000) $19,995 Shares 3,815,930 Est. Cost $5.64 Unrealized -29.9%

UPB UPSTREAM BIO INC 2.6%

Value ($000) $8,145 Shares 300,000 Est. Cost $22.33 Unrealized +11.5%

CNTX CONTEXT THERAPEUTICS INC 2.2%

Value ($000) $6,885 Shares 4,683,711 Est. Cost $1.72 Unrealized -32.2%

ORKA ORUKA THERAPEUTICS INC 1.8%

Value ($000) $5,557 Shares 183,330 Est. Cost $14.82 Unrealized +88.0%

EPRX EUPRAXIA PHARMACEUTICALS INC 2.9%

Value ($000) $9,060 Shares 1,200,000 Est. Cost $5.44 Unrealized +13.3%

UNCY UNICYCIVE THERAPEUTICS INC 1.5%

Value ($000) $4,596 Shares 796,558 Est. Cost $6.18 Unrealized -13.7%

SANA SANA BIOTECHNOLOGY INC 0.9%

Value ($000) $2,849 Shares 700,000 Est. Cost $3.62 Unrealized +23.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ZURA	ZURA BIO LTD	3,815,930	$19,995	6.5%	$5.64	-29.9%	CLASS A ORD SHS	G9TY5A101
UPB	UPSTREAM BIO INC	300,000	$8,145	2.6%	$22.33	+11.5%	COM	91678A107
CNTX	CONTEXT THERAPEUTICS INC	4,683,711	$6,885	2.2%	$1.72	-32.2%	COM	21077P108
ORKA	ORUKA THERAPEUTICS INC	183,330	$5,557	1.8%	$14.82	+88.0%	COM	687604108
EPRX	EUPRAXIA PHARMACEUTICALS INC	1,200,000	$9,060	2.9%	$5.44	+13.3%	COM	29842P105
UNCY	UNICYCIVE THERAPEUTICS INC	796,558	$4,596	1.5%	$6.18	-13.7%	COM NEW	90466Y202
SANA	SANA BIOTECHNOLOGY INC	700,000	$2,849	0.9%	$3.62	+23.9%	COM	799566104