AMYLYX PHARMACEUTICALS INC

Ticker: AMLX CUSIP: 03237H101 Class: Common Stock

GREAT POINT PARTNERS LLC's Holding History (CIK: 0001281446)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,750,000 Value ($000) $21,140 Avg Close $13.58 Range $11.69 - $16.96

Q3 2025

Shares 1,700,000 Value ($000) $23,103 Avg Close $9.41 Range $5.97 - $15.14

Q2 2025

Shares 2,000,000 Value ($000) $12,820 Avg Close $4.86 Range $3.11 - $6.70

Q1 2025

Shares 1,811,996 Value ($000) $6,414 Avg Close $3.56 Range $2.60 - $4.18

Q2 2023

Shares 968,795 Value ($000) $20,897 Avg Close $27.01 Range $20.79 - $31.77

Q1 2023

Shares 783,795 Value ($000) $22,997 Avg Close $34.74 Range $26.64 - $41.93

Q4 2022

Shares 190,000 Value ($000) $7,021 Avg Close $35.49 Range $28.13 - $39.77

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,750,000	$21,140	$13.58	$11.69 - $16.96
Q3 2025	1,700,000	$23,103	$9.41	$5.97 - $15.14
Q2 2025	2,000,000	$12,820	$4.86	$3.11 - $6.70
Q1 2025	1,811,996	$6,414	$3.56	$2.60 - $4.18
Q2 2023	968,795	$20,897	$27.01	$20.79 - $31.77
Q1 2023	783,795	$22,997	$34.74	$26.64 - $41.93
Q4 2022	190,000	$7,021	$35.49	$28.13 - $39.77