Commodore Capital LP Diversified Active

CIK: 0001831942 · Show all filings

Period: Q4 2025 (← Previous)

Filing Date: Feb 17, 2026

Total Value ($000): $1,502,245 (100.0% shares, 0.0% debt)

Holdings (33)

New Positions (6)

ANRO ALTO NEUROSCIENCE INC 2.2%

Value ($000) $32,453 Shares 1,823,196 Est. Cost $12.59 Unrealized 0.0%

PALI PALISADE BIO INC 1.8%

Value ($000) $26,896 Shares 11,445,000 Est. Cost $1.92 Unrealized 0.0%

REPL REPLIMUNE GROUP INC 0.9%

Value ($000) $13,851 Shares 1,425,000 Est. Cost $8.50 Unrealized 0.0%

CTNM CONTINEUM THERAPEUTICS INC 0.6%

Value ($000) $9,331 Shares 816,326 Est. Cost $11.41 Unrealized 0.0%

RAPT RAPT THERAPEUTICS INC 0.6%

Value ($000) $8,468 Shares 250,000 Est. Cost $31.06 Unrealized 0.0%

LONA ATHIRA PHARMA INC 0.2%

Value ($000) $3,515 Shares 464,398 Est. Cost $4.58 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ANRO	ALTO NEUROSCIENCE INC	1,823,196	$32,453	2.2%	$12.59	0.0%	COM SHS	02157Q109
PALI	PALISADE BIO INC	11,445,000	$26,896	1.8%	$1.92	0.0%	COM	696389402
REPL	REPLIMUNE GROUP INC	1,425,000	$13,851	0.9%	$8.50	0.0%	COM	76029N106
CTNM	CONTINEUM THERAPEUTICS INC	816,326	$9,331	0.6%	$11.41	0.0%	CL A	21217B100
RAPT	RAPT THERAPEUTICS INC	250,000	$8,468	0.6%	$31.06	0.0%	COM NEW	75382E208
LONA	ATHIRA PHARMA INC	464,398	$3,515	0.2%	$4.58	0.0%	COM	04746L203

Increased Positions (4)

SYRE SPYRE THERAPEUTICS INC 5.2%

Value ($000) $78,239 (+134.8%) Shares 2,388,245 (+20.1%) Est. Cost $16.69 Unrealized +56.6%

AMLX AMYLYX PHARMACEUTICALS INC 4.5%

Value ($000) $68,252 (+23.2%) Shares 5,650,000 (+38.6%) Est. Cost $10.57 Unrealized +28.4%

PEPG PEPGEN INC 1.5%

Value ($000) $22,134 (+103.2%) Shares 3,400,000 (+44.2%) Est. Cost $2.71 Unrealized +91.6%

ALKS ALKERMES PLC 6.6%

Value ($000) $99,329 (+6.9%) Shares 3,550,000 (+14.6%) Est. Cost $27.24 Unrealized +9.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SYRE	SPYRE THERAPEUTICS INC	2,388,245 (+20.1%)	$78,239 (+134.8%)	5.2%	$16.69	+56.6%	COM NEW	00773J202
AMLX	AMYLYX PHARMACEUTICALS INC	5,650,000 (+38.6%)	$68,252 (+23.2%)	4.5%	$10.57	+28.4%	COM	03237H101
PEPG	PEPGEN INC	3,400,000 (+44.2%)	$22,134 (+103.2%)	1.5%	$2.71	+91.6%	COM	713317105
ALKS	ALKERMES PLC	3,550,000 (+14.6%)	$99,329 (+6.9%)	6.6%	$27.24	+9.9%	SHS	G01767105

Exited Positions (10)

— MERUS N V 22.1%

Value ($000) $331,879 Shares 3,525,000 Est. Cost $29.97 Unrealized —

AGIO AGIOS PHARMACEUTICALS INC 6.2%

Value ($000) $93,859 Shares 2,338,287 Est. Cost $33.00 Unrealized +6.3%

VRDN VIRIDIAN THERAPEUTICS INC 4.6%

Value ($000) $69,056 Shares 3,200,000 Est. Cost $15.97 Unrealized +71.8%

— CIDARA THERAPEUTICS INC 3.7%

Value ($000) $56,020 Shares 585,000 Est. Cost $48.71 Unrealized —

TNGX TANGO THERAPEUTICS INC 0.8%

Value ($000) $12,600 Shares 1,500,000 Est. Cost $2.47 Unrealized +248.5%

APGE APOGEE THERAPEUTICS INC 0.8%

Value ($000) $11,522 Shares 290,000 Est. Cost $25.01 Unrealized +151.8%

ENTA ENANTA PHARMACEUTICALS INC 0.6%

Value ($000) $9,576 Shares 800,000 Est. Cost $7.99 Unrealized +58.9%

PCSC PERCEPTIVE CAP SOLUTIONS COR 0.5%

Value ($000) $7,920 Shares 750,000 Est. Cost $10.07 Unrealized +11.9%

VTGN VISTAGEN THERAPEUTICS INC 0.4%

Value ($000) $5,591 Shares 1,575,000 Est. Cost $4.44 Unrealized -18.6%

CBIO CRESCENT BIOPHARMA INC. 0.4%

Value ($000) $5,360 Shares 450,829 Est. Cost $21.15 Unrealized -39.8%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	MERUS N V	3,525,000	$331,879	22.1%	$29.97	—	—	N5749R100
AGIO	AGIOS PHARMACEUTICALS INC	2,338,287	$93,859	6.2%	$33.00	+6.3%	—	00847X104
VRDN	VIRIDIAN THERAPEUTICS INC	3,200,000	$69,056	4.6%	$15.97	+71.8%	—	92790C104
—	CIDARA THERAPEUTICS INC	585,000	$56,020	3.7%	$48.71	—	—	171757206
TNGX	TANGO THERAPEUTICS INC	1,500,000	$12,600	0.8%	$2.47	+248.5%	—	87583X109
APGE	APOGEE THERAPEUTICS INC	290,000	$11,522	0.8%	$25.01	+151.8%	—	03770N101
ENTA	ENANTA PHARMACEUTICALS INC	800,000	$9,576	0.6%	$7.99	+58.9%	—	29251M106
PCSC	PERCEPTIVE CAP SOLUTIONS COR	750,000	$7,920	0.5%	$10.07	+11.9%	—	G70077105
VTGN	VISTAGEN THERAPEUTICS INC	1,575,000	$5,591	0.4%	$4.44	-18.6%	—	92840H400
CBIO	CRESCENT BIOPHARMA INC.	450,829	$5,360	0.4%	$21.15	-39.8%	—	G2545C104

Decreased Positions (12)

NUVL NUVALENT INC 3.7%

Value ($000) $55,325 (-54.3%) Shares 550,000 (-60.7%) Est. Cost $67.32 Unrealized +46.5%

CNTA CENTESSA PHARMACEUTICALS PLC 1.7%

Value ($000) $25,010 (-63.8%) Shares 1,000,000 (-64.9%) Est. Cost $15.31 Unrealized —

SLNO SOLENO THERAPEUTICS INC 3.7%

Value ($000) $55,560 (-39.1%) Shares 1,200,000 (-11.1%) Est. Cost $58.91 Unrealized -6.9%

DRUG BRIGHT MINDS BIOSCIENCES INC 0.1%

Value ($000) $1,471 (-95.1%) Shares 18,851 (-96.2%) Est. Cost $35.19 Unrealized +89.9%

PTGX PROTAGONIST THERAPEUTICS INC 2.6%

Value ($000) $39,303 (-42.3%) Shares 450,000 (-56.1%) Est. Cost $47.99 Unrealized +70.5%

XENE XENON PHARMACEUTICALS INC 5.4%

Value ($000) $80,676 (-25.6%) Shares 1,800,000 (-33.3%) Est. Cost $30.82 Unrealized +36.3%

COGT COGENT BIOSCIENCES INC 5.2%

Value ($000) $78,032 (-25.0%) Shares 2,196,845 (-69.7%) Est. Cost $10.67 Unrealized +163.6%

TERN TERNS PHARMACEUTICALS INC 4.0%

Value ($000) $59,590 (+39.2%) Shares 1,475,000 (-74.1%) Est. Cost $6.39 Unrealized +261.9%

— MIND MEDICINE MINDMED INC 1.8%

Value ($000) $26,780 (-29.6%) Shares 2,000,000 (-38.0%) Est. Cost $8.32 Unrealized —

CLDX CELLDEX THERAPEUTICS INC NEW 4.6%

Value ($000) $69,665 (-11.1%) Shares 2,565,000 (-15.3%) Est. Cost $22.13 Unrealized +19.0%

NRIX NURIX THERAPEUTICS INC 2.9%

Value ($000) $43,157 (+23.6%) Shares 2,275,000 (-39.8%) Est. Cost $21.29 Unrealized -32.5%

PHVS PHARVARIS N V 3.5%

Value ($000) $52,432 (-13.1%) Shares 1,889,445 (-21.9%) Est. Cost $22.98 Unrealized +4.8%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	550,000 (-60.7%)	$55,325 (-54.3%)	3.7%	$67.32	+46.5%	COM	670703107
CNTA	CENTESSA PHARMACEUTICALS PLC	1,000,000 (-64.9%)	$25,010 (-63.8%)	1.7%	$15.31	—	SPONSORED ADS	152309100
SLNO	SOLENO THERAPEUTICS INC	1,200,000 (-11.1%)	$55,560 (-39.1%)	3.7%	$58.91	-6.9%	COM	834203309
DRUG	BRIGHT MINDS BIOSCIENCES INC	18,851 (-96.2%)	$1,471 (-95.1%)	0.1%	$35.19	+89.9%	COM NEW	10919W405
PTGX	PROTAGONIST THERAPEUTICS INC	450,000 (-56.1%)	$39,303 (-42.3%)	2.6%	$47.99	+70.5%	COM	74366E102
XENE	XENON PHARMACEUTICALS INC	1,800,000 (-33.3%)	$80,676 (-25.6%)	5.4%	$30.82	+36.3%	COM	98420N105
COGT	COGENT BIOSCIENCES INC	2,196,845 (-69.7%)	$78,032 (-25.0%)	5.2%	$10.67	+163.6%	COM	19240Q201
TERN	TERNS PHARMACEUTICALS INC	1,475,000 (-74.1%)	$59,590 (+39.2%)	4.0%	$6.39	+261.9%	COM	880881107
—	MIND MEDICINE MINDMED INC	2,000,000 (-38.0%)	$26,780 (-29.6%)	1.8%	$8.32	—	COM NEW	60255C885
CLDX	CELLDEX THERAPEUTICS INC NEW	2,565,000 (-15.3%)	$69,665 (-11.1%)	4.6%	$22.13	+19.0%	COM NEW	15117B202
NRIX	NURIX THERAPEUTICS INC	2,275,000 (-39.8%)	$43,157 (+23.6%)	2.9%	$21.29	-32.5%	COM	67080M103
PHVS	PHARVARIS N V	1,889,445 (-21.9%)	$52,432 (-13.1%)	3.5%	$22.98	+4.8%	COM	N69605108

Unchanged Positions (11)

RLAY RELAY THERAPEUTICS INC 9.6%

Value ($000) $143,820 Shares 17,000,000 Est. Cost $3.15 Unrealized +126.2%

TYRA TYRA BIOSCIENCES INC 5.9%

Value ($000) $88,729 Shares 3,375,000 Est. Cost $10.62 Unrealized +72.9%

ELVN ENLIVEN THERAPEUTICS INC 4.8%

Value ($000) $72,269 Shares 4,692,809 Est. Cost $19.08 Unrealized +4.4%

ORKA ORUKA THERAPEUTICS INC 3.5%

Value ($000) $53,135 Shares 1,753,054 Est. Cost $30.70 Unrealized -9.2%

KYMR KYMERA THERAPEUTICS INC 3.9%

Value ($000) $58,358 Shares 750,000 Est. Cost $34.43 Unrealized +96.1%

LBRX LB PHARMACEUTICALS INC 2.2%

Value ($000) $33,390 Shares 1,500,000 Est. Cost $15.87 Unrealized +10.1%

ASMB ASSEMBLY BIOSCIENCES INC 2.3%

Value ($000) $34,010 Shares 1,000,000 Est. Cost $21.94 Unrealized +46.8%

CTMX CYTOMX THERAPEUTICS INC 2.2%

Value ($000) $32,769 Shares 7,692,300 Est. Cost $1.61 Unrealized +135.7%

SABS SAB BIOTHERAPEUTICS INC 1.1%

Value ($000) $16,462 Shares 4,401,500 Est. Cost $2.26 Unrealized +45.5%

AVTX AVALO THERAPEUTICS INC 0.6%

Value ($000) $8,771 Shares 483,000 Est. Cost $10.53 Unrealized +60.3%

IKT INHIBIKASE THERAPEUTICS INC 0.7%

Value ($000) $11,065 Shares 5,397,488 Est. Cost $2.49 Unrealized -36.2%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
RLAY	RELAY THERAPEUTICS INC	17,000,000	$143,820	9.6%	$3.15	+126.2%	COM	75943R102
TYRA	TYRA BIOSCIENCES INC	3,375,000	$88,729	5.9%	$10.62	+72.9%	COM	90240B106
ELVN	ENLIVEN THERAPEUTICS INC	4,692,809	$72,269	4.8%	$19.08	+4.4%	COM	29337E102
ORKA	ORUKA THERAPEUTICS INC	1,753,054	$53,135	3.5%	$30.70	-9.2%	COM	687604108
KYMR	KYMERA THERAPEUTICS INC	750,000	$58,358	3.9%	$34.43	+96.1%	COM	501575104
LBRX	LB PHARMACEUTICALS INC	1,500,000	$33,390	2.2%	$15.87	+10.1%	COM SHS	50180M108
ASMB	ASSEMBLY BIOSCIENCES INC	1,000,000	$34,010	2.3%	$21.94	+46.8%	COM NEW	045396207
CTMX	CYTOMX THERAPEUTICS INC	7,692,300	$32,769	2.2%	$1.61	+135.7%	COM	23284F105
SABS	SAB BIOTHERAPEUTICS INC	4,401,500	$16,462	1.1%	$2.26	+45.5%	COM NEW	78397T202
AVTX	AVALO THERAPEUTICS INC	483,000	$8,771	0.6%	$10.53	+60.3%	COM NEW	05338F306
IKT	INHIBIKASE THERAPEUTICS INC	5,397,488	$11,065	0.7%	$2.49	-36.2%	COM NEW	45719W205