Octagon Capital Advisors LP Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CGON	CG ONCOLOGY INC	600,000	$24,912	3.0%	—	—	CALL	156944100
ALMS	ALUMIS INC	2,530,700	$24,700	3.0%	$6.98	0.0%	COM	022307102
PALI	PALISADE BIO INC	9,567,898	$22,485	2.7%	$1.92	0.0%	COM	696389402
BIOA	BIOAGE LABS INC	1,598,000	$21,142	2.6%	$8.86	0.0%	COM	09077V100
RAPT	RAPT THERAPEUTICS INC	574,000	$19,441	2.4%	$31.06	0.0%	COM NEW	75382E208
LXEO	LEXEO THERAPEUTICS INC	1,725,000	$17,129	2.1%	$9.13	0.0%	COM	52886X107
EVMN	EVOMMUNE INC	500,000	$8,560	1.0%	$18.78	0.0%	COM SHS	30054Y107
DTIL	PRECISION BIOSCIENCES INC	1,917,995	$7,979	1.0%	$5.68	0.0%	COM NEW	74019P207

Increased Positions (2)

KYMR KYMERA THERAPEUTICS INC 5.1%

Value ($000) $41,628 (+104.3%) Shares 535,000 (+48.6%) Est. Cost $47.13 Unrealized +43.3%

— MIND MEDICINE MINDMED INC 3.6%

Value ($000) $29,860 (+18.9%) Shares 2,230,000 (+4.7%) Est. Cost $8.56 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
KYMR	KYMERA THERAPEUTICS INC	535,000 (+48.6%)	$41,628 (+104.3%)	5.1%	$47.13	+43.3%	COM	501575104
—	MIND MEDICINE MINDMED INC	2,230,000 (+4.7%)	$29,860 (+18.9%)	3.6%	$8.56	—	COM NEW	60255C885

Exited Positions (8)

— MERUS N V 3.5%

Value ($000) $28,998 Shares 308,000 Est. Cost $44.25 Unrealized —

APLS APELLIS PHARMACEUTICALS INC 2.5%

Value ($000) $20,446 Shares 903,500 Est. Cost $47.09 Unrealized -50.2%

— CIDARA THERAPEUTICS INC 2.3%

Value ($000) $19,152 Shares 200,000 Est. Cost $95.76 Unrealized —

NUVB NUVATION BIO INC 1.2%

Value ($000) $9,743 Shares 2,633,334 Est. Cost $2.99 Unrealized +106.9%

MAZE MAZE THERAPEUTICS INC 0.6%

Value ($000) $4,607 Shares 177,667 Est. Cost $12.04 Unrealized +185.5%

NGNE NEUROGENE INC 0.5%

Value ($000) $4,367 Shares 252,000 Est. Cost $37.29 Unrealized -33.2%

GPCR STRUCTURE THERAPEUTICS INC 0.4%

Value ($000) $3,220 Shares 115,000 Est. Cost $28.00 Unrealized —

— NUVATION BIO INC 0.0%

Value ($000) $385 Shares 104,112 Est. Cost $1.77 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	MERUS N V	308,000	$28,998	3.5%	$44.25	—	—	N5749R100
APLS	APELLIS PHARMACEUTICALS INC	903,500	$20,446	2.5%	$47.09	-50.2%	—	03753U106
—	CIDARA THERAPEUTICS INC	200,000	$19,152	2.3%	$95.76	—	CALL	171757206
NUVB	NUVATION BIO INC	2,633,334	$9,743	1.2%	$2.99	+106.9%	—	67080N101
MAZE	MAZE THERAPEUTICS INC	177,667	$4,607	0.6%	$12.04	+185.5%	—	578784100
NGNE	NEUROGENE INC	252,000	$4,367	0.5%	$37.29	-33.2%	—	64135M105
GPCR	STRUCTURE THERAPEUTICS INC	115,000	$3,220	0.4%	$28.00	—	—	86366E106
—	NUVATION BIO INC	104,112	$385	0.0%	$1.77	—	—	67080N119

Decreased Positions (8)

COGT COGENT BIOSCIENCES INC 10.1%

Value ($000) $83,472 (+102.2%) Shares 2,350,000 (-18.2%) Est. Cost $9.93 Unrealized +183.0%

TSHA TAYSHA GENE THERAPIES INC 5.9%

Value ($000) $48,730 (+64.3%) Shares 8,859,911 (-2.3%) Est. Cost $2.19 Unrealized +122.2%

ABVX ABIVAX SA 12.4%

Value ($000) $101,950 (-9.4%) Shares 756,000 (-42.9%) Est. Cost $9.73 Unrealized —

CRBP CORBUS PHARMACEUTICALS HLDGS 0.9%

Value ($000) $7,774 (-44.9%) Shares 955,000 (-14.3%) Est. Cost $40.87 Unrealized -69.8%

GOSS GOSSAMER BIO INC 5.2%

Value ($000) $43,138 (-3.8%) Shares 13,915,371 (-18.4%) Est. Cost $1.89 Unrealized +50.7%

CNTA CENTESSA PHARMACEUTICALS PLC 2.3%

Value ($000) $18,758 (-6.8%) Shares 750,000 (-9.6%) Est. Cost $7.34 Unrealized —

DBVT DBV TECHNOLOGIES S A 1.3%

Value ($000) $11,007 (+8.1%) Shares 574,200 (-43.6%) Est. Cost $9.15 Unrealized —

PHVS PHARVARIS N V 2.3%

Value ($000) $18,633 (+3.4%) Shares 671,465 (-7.1%) Est. Cost $18.98 Unrealized +26.9%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
COGT	COGENT BIOSCIENCES INC	2,350,000 (-18.2%)	$83,472 (+102.2%)	10.1%	$9.93	+183.0%	COM	19240Q201
TSHA	TAYSHA GENE THERAPIES INC	8,859,911 (-2.3%)	$48,730 (+64.3%)	5.9%	$2.19	+122.2%	COM SHS	877619106
ABVX	ABIVAX SA	756,000 (-42.9%)	$101,950 (-9.4%)	12.4%	$9.73	—	SPONSORED ADS	00370M103
CRBP	CORBUS PHARMACEUTICALS HLDGS	955,000 (-14.3%)	$7,774 (-44.9%)	0.9%	$40.87	-69.8%	COM NEW	21833P301
GOSS	GOSSAMER BIO INC	13,915,371 (-18.4%)	$43,138 (-3.8%)	5.2%	$1.89	+50.7%	COM	38341P102
CNTA	CENTESSA PHARMACEUTICALS PLC	750,000 (-9.6%)	$18,758 (-6.8%)	2.3%	$7.34	—	SPONSORED ADS	152309100
DBVT	DBV TECHNOLOGIES S A	574,200 (-43.6%)	$11,007 (+8.1%)	1.3%	$9.15	—	SPONSORED ADS	23306J309
PHVS	PHARVARIS N V	671,465 (-7.1%)	$18,633 (+3.4%)	2.3%	$18.98	+26.9%	COM	N69605108

Unchanged Positions (9)

— CIDARA THERAPEUTICS INC 2.7%

Value ($000) $22,089 Shares 100,000 Est. Cost $95.76 Unrealized —

TRVI TREVI THERAPEUTICS INC 4.3%

Value ($000) $35,244 Shares 2,815,000 Est. Cost $4.91 Unrealized +135.5%

KALV KALVISTA PHARMACEUTICALS INC 2.5%

Value ($000) $20,564 Shares 1,273,333 Est. Cost $10.36 Unrealized +27.9%

DNTH DIANTHUS THERAPEUTICS INC 12.1%

Value ($000) $99,591 Shares 2,416,667 Est. Cost $20.69 Unrealized +87.4%

AVBP ARRIVENT BIOPHARMA INC 4.8%

Value ($000) $39,658 Shares 1,971,054 Est. Cost $20.71 Unrealized +0.5%

UNCY UNICYCIVE THERAPEUTICS INC 0.7%

Value ($000) $5,770 Shares 1,000,000 Est. Cost $6.18 Unrealized -13.7%

PEPG PEPGEN INC 0.6%

Value ($000) $4,557 Shares 700,000 Est. Cost $1.61 Unrealized +222.0%

OCUL OCULAR THERAPEUTIX INC 3.9%

Value ($000) $31,851 Shares 2,623,600 Est. Cost $7.47 Unrealized +62.7%

BBOT BRIDGEBIO ONCOLOGY THERAPEUT 1.6%

Value ($000) $13,060 Shares 1,043,110 Est. Cost $11.58 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	CIDARA THERAPEUTICS INC	100,000	$22,089	2.7%	$95.76	—	COM NEW	171757206
TRVI	TREVI THERAPEUTICS INC	2,815,000	$35,244	4.3%	$4.91	+135.5%	COM	89532M101
KALV	KALVISTA PHARMACEUTICALS INC	1,273,333	$20,564	2.5%	$10.36	+27.9%	COM	483497103
DNTH	DIANTHUS THERAPEUTICS INC	2,416,667	$99,591	12.1%	$20.69	+87.4%	COM	252828108
AVBP	ARRIVENT BIOPHARMA INC	1,971,054	$39,658	4.8%	$20.71	+0.5%	COM	04272N102
UNCY	UNICYCIVE THERAPEUTICS INC	1,000,000	$5,770	0.7%	$6.18	-13.7%	COM NEW	90466Y202
PEPG	PEPGEN INC	700,000	$4,557	0.6%	$1.61	+222.0%	COM	713317105
OCUL	OCULAR THERAPEUTIX INC	2,623,600	$31,851	3.9%	$7.47	+62.7%	COM	67576A100
BBOT	BRIDGEBIO ONCOLOGY THERAPEUT	1,043,110	$13,060	1.6%	$11.58	—	COM NEW	107924102