Artia Global Partners LP Quant / Systematic

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
INSM	INSMED INC	420,000	$73,097	10.4%	$72.29	+152.4%	PUT	457669307
—	CIDARA THERAPEUTICS INC	70,824	$15,644	2.2%	$220.89	—	COM NEW	171757206
VTYX	VENTYX BIOSCIENCES INC	695,982	$6,285	0.9%	$7.47	0.0%	COM	92332V107
PVLA	PALVELLA THERAPEUTICS INC NE	59,200	$6,196	0.9%	$85.31	0.0%	COM	697947109
UGL	PROSHARES TR II	100,000	$5,552	0.8%	$46.06	—	PUT	74347W601
SION	SIONNA THERAPEUTICS INC	119,741	$4,926	0.7%	$37.92	0.0%	COM	829401108
PALI	PALISADE BIO INC	1,992,367	$4,682	0.7%	$1.92	0.0%	COM	696389402
PROK	PROKIDNEY CORP	1,838,411	$4,118	0.6%	$2.63	0.0%	SHS CL A	74291D104
BLTE	BELITE BIO INC	17,989	$2,878	0.4%	$159.96	—	SPONSORED ADS	07782B104
ROIV	ROIVANT SCIENCES LTD	129,800	$2,817	0.4%	$19.73	0.0%	SHS	G76279101
DRUG	BRIGHT MINDS BIOSCIENCES INC	33,407	$2,607	0.4%	$66.83	0.0%	COM NEW	10919W405
SLNO	SOLENO THERAPEUTICS INC	50,000	$2,315	0.3%	$55.51	-1.2%	CALL	834203309
UPB	UPSTREAM BIO INC	68,653	$1,864	0.3%	$24.89	0.0%	COM	91678A107
PEPG	PEPGEN INC	205,324	$1,337	0.2%	$5.19	0.0%	COM	713317105
ABVX	ABIVAX SA	9,900	$1,335	0.2%	$116.11	—	CALL	00370M103
CELC	CELCUITY INC	12,900	$1,287	0.2%	$82.21	0.0%	COM	15102K100
OCUL	OCULAR THERAPEUTIX INC	85,200	$1,034	0.1%	$11.96	+1.6%	CALL	67576A100
NUVL	NUVALENT INC	8,100	$815	0.1%	$98.60	0.0%	COM	670703107
AVTX	AVALO THERAPEUTICS INC	41,570	$755	0.1%	$16.88	0.0%	COM NEW	05338F306
PRAX	PRAXIS PRECISION MEDICINES I	2,500	$737	0.1%	$186.22	0.0%	COM NEW	74006W207
ANRO	ALTO NEUROSCIENCE INC	29,192	$520	0.1%	$12.59	0.0%	COM SHS	02157Q109
TENX	TENAX THERAPEUTICS INC	42,080	$513	0.1%	$8.70	0.0%	COM NEW	88032L605
KOD	KODIAK SCIENCES INC	17,019	$476	0.1%	$20.48	0.0%	COM	50015M109
LYRA	LYRA THERAPEUTICS INC	8,756	$27	0.0%	$4.98	0.0%	COM NEW	55234L204

Increased Positions (12)

ABVX ABIVAX SA 11.5%

Value ($000) $81,014 (+323.2%) Shares 600,747 (+166.5%) Est. Cost $116.11 Unrealized —

LLY ELI LILLY & CO 7.7%

Value ($000) $54,271 (+147.8%) Shares 50,500 (+76.0%) Est. Cost $882.32 Unrealized +8.3%

VKTX VIKING THERAPEUTICS INC 3.6%

Value ($000) $25,307 (+558.8%) Shares 719,365 (+392.1%) Est. Cost $34.07 Unrealized +4.0%

QURE UNIQURE NV 3.5%

Value ($000) $24,493 (-36.3%) Shares 1,023,539 (+55.4%) Est. Cost $25.44 Unrealized +51.7%

NAMS NEWAMSTERDAM PHARMA COMPANY 2.5%

Value ($000) $17,678 (+219.0%) Shares 503,936 (+158.6%) Est. Cost $31.28 Unrealized +16.3%

IONS IONIS PHARMACEUTICALS INC 1.6%

Value ($000) $11,422 (+190.1%) Shares 144,376 (+139.9%) Est. Cost $64.26 Unrealized +17.2%

EYPT EYEPOINT PHARMACEUTICALS INC 2.0%

Value ($000) $14,015 (+56.6%) Shares 767,098 (+22.1%) Est. Cost $11.20 Unrealized +26.5%

DNTH DIANTHUS THERAPEUTICS INC 1.2%

Value ($000) $8,452 (+97.6%) Shares 205,090 (+88.6%) Est. Cost $31.76 Unrealized +22.1%

MLYS MINERALYS THERAPEUTICS INC 0.7%

Value ($000) $5,001 (+133.0%) Shares 137,800 (+143.5%) Est. Cost $30.39 Unrealized +32.0%

RAPP RAPPORT THERAPEUTICS INC 0.6%

Value ($000) $4,202 (+119.0%) Shares 138,508 (+114.4%) Est. Cost $23.09 Unrealized +19.9%

TVTX TRAVERE THERAPEUTICS INC 0.4%

Value ($000) $2,701 (+265.8%) Shares 70,700 (+128.8%) Est. Cost $27.18 Unrealized +19.7%

ASND ASCENDIS PHARMA A/S 0.5%

Value ($000) $3,783 (+55.5%) Shares 17,740 (+44.9%) Est. Cost $176.21 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
ABVX	ABIVAX SA	600,747 (+166.5%)	$81,014 (+323.2%)	11.5%	$116.11	—	SPONSORED ADS	00370M103
LLY	ELI LILLY & CO	50,500 (+76.0%)	$54,271 (+147.8%)	7.7%	$882.32	+8.3%	COM	532457108
VKTX	VIKING THERAPEUTICS INC	719,365 (+392.1%)	$25,307 (+558.8%)	3.6%	$34.07	+4.0%	COM	92686J106
QURE	UNIQURE NV	1,023,539 (+55.4%)	$24,493 (-36.3%)	3.5%	$25.44	+51.7%	SHS	N90064101
NAMS	NEWAMSTERDAM PHARMA COMPANY	503,936 (+158.6%)	$17,678 (+219.0%)	2.5%	$31.28	+16.3%	ORDINARY SHARES	N62509109
IONS	IONIS PHARMACEUTICALS INC	144,376 (+139.9%)	$11,422 (+190.1%)	1.6%	$64.26	+17.2%	COM	462222100
EYPT	EYEPOINT PHARMACEUTICALS INC	767,098 (+22.1%)	$14,015 (+56.6%)	2.0%	$11.20	+26.5%	COM NEW	30233G209
DNTH	DIANTHUS THERAPEUTICS INC	205,090 (+88.6%)	$8,452 (+97.6%)	1.2%	$31.76	+22.1%	COM	252828108
MLYS	MINERALYS THERAPEUTICS INC	137,800 (+143.5%)	$5,001 (+133.0%)	0.7%	$30.39	+32.0%	COM	603170101
RAPP	RAPPORT THERAPEUTICS INC	138,508 (+114.4%)	$4,202 (+119.0%)	0.6%	$23.09	+19.9%	COM	75383L102
TVTX	TRAVERE THERAPEUTICS INC	70,700 (+128.8%)	$2,701 (+265.8%)	0.4%	$27.18	+19.7%	COM	89422G107
ASND	ASCENDIS PHARMA A/S	17,740 (+44.9%)	$3,783 (+55.5%)	0.5%	$176.21	—	SPONSORED ADR	04351P101

Exited Positions (20)

INSM INSMED INC 8.2%

Value ($000) $57,604 Shares 400,000 Est. Cost $72.29 Unrealized +152.4%

— VERONA PHARMA PLC 5.7%

Value ($000) $40,444 Shares 379,004 Est. Cost $67.66 Unrealized —

— MERUS N V 4.0%

Value ($000) $27,939 Shares 296,750 Est. Cost $42.88 Unrealized —

VRTX VERTEX PHARMACEUTICALS INC 3.1%

Value ($000) $21,579 Shares 55,100 Est. Cost $421.35 Unrealized +2.3%

BSX BOSTON SCIENTIFIC CORP 2.5%

Value ($000) $17,886 Shares 183,200 Est. Cost $101.20 Unrealized -3.1%

REGN REGENERON PHARMACEUTICALS 0.9%

Value ($000) $6,000 Shares 10,671 Est. Cost $556.12 Unrealized +22.0%

RARE ULTRAGENYX PHARMACEUTICAL IN 0.6%

Value ($000) $4,512 Shares 150,000 Est. Cost $33.92 Unrealized -3.1%

NKTR NEKTAR THERAPEUTICS 0.5%

Value ($000) $3,300 Shares 57,999 Est. Cost $33.10 Unrealized +69.1%

CNTA CENTESSA PHARMACEUTICALS PLC 0.5%

Value ($000) $3,232 Shares 133,291 Est. Cost $24.25 Unrealized —

TGTX TG THERAPEUTICS INC 0.3%

Value ($000) $1,969 Shares 54,515 Est. Cost $28.70 Unrealized +13.8%

RARE ULTRAGENYX PHARMACEUTICAL IN 0.3%

Value ($000) $1,940 Shares 64,502 Est. Cost $33.92 Unrealized -3.1%

IREN IREN LIMITED 0.2%

Value ($000) $1,558 Shares 33,200 Est. Cost $24.29 Unrealized +112.4%

BHVN BIOHAVEN LTD 0.2%

Value ($000) $1,201 Shares 80,000 Est. Cost $17.82 Unrealized -30.5%

MREO MEREO BIOPHARMA GROUP PLC 0.1%

Value ($000) $979 Shares 475,361 Est. Cost $3.23 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 0.1%

Value ($000) $865 Shares 44,900 Est. Cost $17.83 Unrealized +18.2%

MRNA MODERNA INC 0.1%

Value ($000) $615 Shares 23,800 Est. Cost $27.90 Unrealized -2.6%

KALV KALVISTA PHARMACEUTICALS INC 0.1%

Value ($000) $506 Shares 41,555 Est. Cost $13.82 Unrealized -4.2%

ATYR ATYR PHARMA INC 0.1%

Value ($000) $433 Shares 600,000 Est. Cost $4.53 Unrealized -81.9%

ATYR ATYR PHARMA INC 0.0%

Value ($000) $269 Shares 372,276 Est. Cost $4.53 Unrealized -81.9%

ALEC ALECTOR INC 0.0%

Value ($000) $210 Shares 71,029 Est. Cost $2.20 Unrealized -19.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
INSM	INSMED INC	400,000	$57,604	8.2%	$72.29	+152.4%	CALL	457669307
—	VERONA PHARMA PLC	379,004	$40,444	5.7%	$67.66	—	—	925050106
—	MERUS N V	296,750	$27,939	4.0%	$42.88	—	—	N5749R100
VRTX	VERTEX PHARMACEUTICALS INC	55,100	$21,579	3.1%	$421.35	+2.3%	—	92532F100
BSX	BOSTON SCIENTIFIC CORP	183,200	$17,886	2.5%	$101.20	-3.1%	—	101137107
REGN	REGENERON PHARMACEUTICALS	10,671	$6,000	0.9%	$556.12	+22.0%	—	75886F107
RARE	ULTRAGENYX PHARMACEUTICAL IN	150,000	$4,512	0.6%	$33.92	-3.1%	CALL	90400D108
NKTR	NEKTAR THERAPEUTICS	57,999	$3,300	0.5%	$33.10	+69.1%	—	640268306
CNTA	CENTESSA PHARMACEUTICALS PLC	133,291	$3,232	0.5%	$24.25	—	—	152309100
TGTX	TG THERAPEUTICS INC	54,515	$1,969	0.3%	$28.70	+13.8%	—	88322Q108
RARE	ULTRAGENYX PHARMACEUTICAL IN	64,502	$1,940	0.3%	$33.92	-3.1%	—	90400D108
IREN	IREN LIMITED	33,200	$1,558	0.2%	$24.29	+112.4%	—	Q4982L109
BHVN	BIOHAVEN LTD	80,000	$1,201	0.2%	$17.82	-30.5%	—	G1110E107
MREO	MEREO BIOPHARMA GROUP PLC	475,361	$979	0.1%	$3.23	—	—	589492107
SRPT	SAREPTA THERAPEUTICS INC	44,900	$865	0.1%	$17.83	+18.2%	—	803607100
MRNA	MODERNA INC	23,800	$615	0.1%	$27.90	-2.6%	—	60770K107
KALV	KALVISTA PHARMACEUTICALS INC	41,555	$506	0.1%	$13.82	-4.2%	—	483497103
ATYR	ATYR PHARMA INC	600,000	$433	0.1%	$4.53	-81.9%	CALL	002120202
ATYR	ATYR PHARMA INC	372,276	$269	0.0%	$4.53	-81.9%	—	002120202
ALEC	ALECTOR INC	71,029	$210	0.0%	$2.20	-19.5%	—	014442107

Decreased Positions (7)

SLNO SOLENO THERAPEUTICS INC 3.5%

Value ($000) $24,710 (-45.6%) Shares 533,698 (-20.6%) Est. Cost $55.51 Unrealized -1.2%

INSM INSMED INC 16.8%

Value ($000) $118,732 (+12.6%) Shares 682,212 (-6.8%) Est. Cost $72.29 Unrealized +152.4%

ALNY ALNYLAM PHARMACEUTICALS INC 1.0%

Value ($000) $6,919 (-56.1%) Shares 17,400 (-49.7%) Est. Cost $280.16 Unrealized +58.0%

DGX QUEST DIAGNOSTICS INC 1.0%

Value ($000) $7,083 (-54.5%) Shares 40,817 (-50.1%) Est. Cost $165.04 Unrealized +10.3%

ARGX ARGENX SE 7.7%

Value ($000) $54,409 (-5.8%) Shares 64,699 (-17.4%) Est. Cost $527.57 Unrealized —

RNA AVIDITY BIOSCIENCES INC 0.6%

Value ($000) $4,335 (-9.6%) Shares 60,100 (-45.4%) Est. Cost $37.09 Unrealized +74.2%

UGL PROSHARES TR II 3.5%

Value ($000) $24,546 (-0.8%) Shares 442,119 (-17.7%) Est. Cost $46.06 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SLNO	SOLENO THERAPEUTICS INC	533,698 (-20.6%)	$24,710 (-45.6%)	3.5%	$55.51	-1.2%	COM	834203309
INSM	INSMED INC	682,212 (-6.8%)	$118,732 (+12.6%)	16.8%	$72.29	+152.4%	COM PAR $.01	457669307
ALNY	ALNYLAM PHARMACEUTICALS INC	17,400 (-49.7%)	$6,919 (-56.1%)	1.0%	$280.16	+58.0%	COM	02043Q107
DGX	QUEST DIAGNOSTICS INC	40,817 (-50.1%)	$7,083 (-54.5%)	1.0%	$165.04	+10.3%	COM	74834L100
ARGX	ARGENX SE	64,699 (-17.4%)	$54,409 (-5.8%)	7.7%	$527.57	—	SPONSORED ADR	04016X101
RNA	AVIDITY BIOSCIENCES INC	60,100 (-45.4%)	$4,335 (-9.6%)	0.6%	$37.09	+74.2%	COM	05370A108
UGL	PROSHARES TR II	442,119 (-17.7%)	$24,546 (-0.8%)	3.5%	$46.06	—	ULTRA GOLD	74347W601

Unchanged Positions (12)

TRVI TREVI THERAPEUTICS INC 3.6%

Value ($000) $25,210 Shares 2,013,602 Est. Cost $6.66 Unrealized +73.5%

RVMD REVOLUTION MEDICINES INC 1.2%

Value ($000) $8,299 Shares 104,190 Est. Cost $48.13 Unrealized +36.2%

AZN ASTRAZENECA PLC 2.5%

Value ($000) $17,536 Shares 190,752 Est. Cost $69.76 Unrealized —

SRRK SCHOLAR ROCK HLDG CORP 0.6%

Value ($000) $4,241 Shares 96,285 Est. Cost $38.47 Unrealized -2.5%

BBIO BRIDGEBIO PHARMA INC 0.2%

Value ($000) $1,560 Shares 20,400 Est. Cost $48.77 Unrealized +34.6%

PTGX PROTAGONIST THERAPEUTICS INC 0.3%

Value ($000) $2,005 Shares 22,951 Est. Cost $36.55 Unrealized +123.9%

UTHR UNITED THERAPEUTICS CORP DEL 0.3%

Value ($000) $2,436 Shares 5,000 Est. Cost $342.70 Unrealized +35.9%

BTSG BRIGHTSPRING HEALTH SVCS INC 0.2%

Value ($000) $1,558 Shares 41,600 Est. Cost $23.24 Unrealized +44.3%

XENE XENON PHARMACEUTICALS INC 0.3%

Value ($000) $1,793 Shares 40,000 Est. Cost $46.00 Unrealized -8.7%

KNSA KINIKSA PHARMACEUTICALS INTL 0.2%

Value ($000) $1,205 Shares 29,200 Est. Cost $25.46 Unrealized +57.6%

OCUL OCULAR THERAPEUTIX INC 0.2%

Value ($000) $1,712 Shares 141,061 Est. Cost $11.96 Unrealized +1.6%

ABBV ABBVIE INC 0.5%

Value ($000) $3,313 Shares 14,500 Est. Cost $182.67 Unrealized +24.6%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
TRVI	TREVI THERAPEUTICS INC	2,013,602	$25,210	3.6%	$6.66	+73.5%	COM	89532M101
RVMD	REVOLUTION MEDICINES INC	104,190	$8,299	1.2%	$48.13	+36.2%	COM	76155X100
AZN	ASTRAZENECA PLC	190,752	$17,536	2.5%	$69.76	—	SPONSORED ADR	046353108
SRRK	SCHOLAR ROCK HLDG CORP	96,285	$4,241	0.6%	$38.47	-2.5%	COM	80706P103
BBIO	BRIDGEBIO PHARMA INC	20,400	$1,560	0.2%	$48.77	+34.6%	COM	10806X102
PTGX	PROTAGONIST THERAPEUTICS INC	22,951	$2,005	0.3%	$36.55	+123.9%	COM	74366E102
UTHR	UNITED THERAPEUTICS CORP DEL	5,000	$2,436	0.3%	$342.70	+35.9%	COM	91307C102
BTSG	BRIGHTSPRING HEALTH SVCS INC	41,600	$1,558	0.2%	$23.24	+44.3%	COM	10950A106
XENE	XENON PHARMACEUTICALS INC	40,000	$1,793	0.3%	$46.00	-8.7%	COM	98420N105
KNSA	KINIKSA PHARMACEUTICALS INTL	29,200	$1,205	0.2%	$25.46	+57.6%	ORD SHS CL A	G52694109
OCUL	OCULAR THERAPEUTIX INC	141,061	$1,712	0.2%	$11.96	+1.6%	COM	67576A100
ABBV	ABBVIE INC	14,500	$3,313	0.5%	$182.67	+24.6%	COM	00287Y109