Spruce Street Capital LP Concentrated Active

CIK: 0002050194 · Show all filings

Period: Q4 2025

Filing Date: Feb 13, 2026

Total Value ($000): $302,660 (100.0% shares, 0.0% debt)

Holdings (27)

— CIDARA THERAPEUTICS INC 17.0%

Value ($000) $51,306 Shares 232,269 Est. Cost $220.89 Unrealized —

RLAY RELAY THERAPEUTICS INC 8.3%

Value ($000) $25,246 Shares 2,984,125 Est. Cost $7.14 Unrealized 0.0%

LBRX LB PHARMACEUTICALS INC 7.4%

Value ($000) $22,385 Shares 1,005,593 Est. Cost $17.47 Unrealized 0.0%

RLMD RELMADA THERAPEUTICS INC 6.5%

Value ($000) $19,736 Shares 4,086,181 Est. Cost $3.35 Unrealized 0.0%

PCVX VAXCYTE INC 6.1%

Value ($000) $18,473 Shares 400,360 Est. Cost $44.73 Unrealized 0.0%

KNSA KINIKSA PHARMACEUTICALS INTL 5.9%

Value ($000) $17,943 Shares 434,982 Est. Cost $40.11 Unrealized 0.0%

EYPT EYEPOINT INC 5.9%

Value ($000) $17,933 Shares 981,543 Est. Cost $14.17 Unrealized 0.0%

SVRA SAVARA INC 4.8%

Value ($000) $14,539 Shares 2,411,093 Est. Cost $4.90 Unrealized 0.0%

ERAS ERASCA INC 4.8%

Value ($000) $14,469 Shares 3,889,632 Est. Cost $2.81 Unrealized 0.0%

DNTH DIANTHUS THERAPEUTICS INC 4.0%

Value ($000) $12,257 Shares 297,437 Est. Cost $38.77 Unrealized 0.0%

SRZN SURROZEN INC 3.2%

Value ($000) $9,764 Shares 432,040 Est. Cost $16.18 Unrealized 0.0%

OCUL OCULAR THERAPEUTIX INC 3.1%

Value ($000) $9,518 Shares 783,999 Est. Cost $12.15 Unrealized 0.0%

SABS SAB BIOTHERAPEUTICS INC 2.7%

Value ($000) $8,222 Shares 2,198,502 Est. Cost $3.29 Unrealized 0.0%

IKT INHIBIKASE THERAPEUTICS INC 2.4%

Value ($000) $7,342 Shares 3,581,603 Est. Cost $1.59 Unrealized 0.0%

ELVN ENLIVEN THERAPEUTICS INC 2.3%

Value ($000) $6,870 Shares 446,084 Est. Cost $19.92 Unrealized 0.0%

NERV MINERVA NEUROSCIENCES INC 2.2%

Value ($000) $6,655 Shares 1,655,500 Est. Cost $3.71 Unrealized 0.0%

ABVX ABIVAX SA 2.2%

Value ($000) $6,624 Shares 49,119 Est. Cost $134.86 Unrealized —

HELP CYBIN INC 2.1%

Value ($000) $6,299 Shares 770,000 Est. Cost $6.44 Unrealized 0.0%

KALV KALVISTA PHARMACEUTICALS INC 2.1%

Value ($000) $6,266 Shares 387,968 Est. Cost $13.24 Unrealized 0.0%

ENTA ENANTA PHARMACEUTICALS INC 2.0%

Value ($000) $6,145 Shares 389,687 Est. Cost $12.70 Unrealized 0.0%

ANRO ALTO NEUROSCIENCE INC 1.3%

Value ($000) $3,967 Shares 222,844 Est. Cost $12.59 Unrealized 0.0%

LONA ATHIRA PHARMA INC 1.0%

Value ($000) $2,980 Shares 393,701 Est. Cost $4.58 Unrealized 0.0%

CNTA CENTESSA PHARMACEUTICALS PLC 0.6%

Value ($000) $1,951 Shares 77,997 Est. Cost $25.01 Unrealized —

ALEC ALECTOR INC 0.6%

Value ($000) $1,744 Shares 1,117,986 Est. Cost $1.77 Unrealized 0.0%

LXEO LEXEO THERAPEUTICS INC 0.6%

Value ($000) $1,738 Shares 175,000 Est. Cost $9.13 Unrealized 0.0%

IPSC CENTURY THERAPEUTICS INC 0.5%

Value ($000) $1,414 Shares 1,421,532 Est. Cost $0.61 Unrealized 0.0%

STRO SUTRO BIOPHARMA INC 0.3%

Value ($000) $875 Shares 75,594 Est. Cost $9.49 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	CIDARA THERAPEUTICS INC	232,269	$51,306	17.0%	$220.89	—	COM NEW	171757206
RLAY	RELAY THERAPEUTICS INC	2,984,125	$25,246	8.3%	$7.14	0.0%	COM	75943R102
LBRX	LB PHARMACEUTICALS INC	1,005,593	$22,385	7.4%	$17.47	0.0%	COM SHS	50180M108
RLMD	RELMADA THERAPEUTICS INC	4,086,181	$19,736	6.5%	$3.35	0.0%	COM	75955J402
PCVX	VAXCYTE INC	400,360	$18,473	6.1%	$44.73	0.0%	COM	92243G108
KNSA	KINIKSA PHARMACEUTICALS INTL	434,982	$17,943	5.9%	$40.11	0.0%	ORD SHS CL A	G52694109
EYPT	EYEPOINT INC	981,543	$17,933	5.9%	$14.17	0.0%	COM NEW	30233G209
SVRA	SAVARA INC	2,411,093	$14,539	4.8%	$4.90	0.0%	COM	805111101
ERAS	ERASCA INC	3,889,632	$14,469	4.8%	$2.81	0.0%	COM	29479A108
DNTH	DIANTHUS THERAPEUTICS INC	297,437	$12,257	4.0%	$38.77	0.0%	COM	252828108
SRZN	SURROZEN INC	432,040	$9,764	3.2%	$16.18	0.0%	COM NEW	86889P208
OCUL	OCULAR THERAPEUTIX INC	783,999	$9,518	3.1%	$12.15	0.0%	COM	67576A100
SABS	SAB BIOTHERAPEUTICS INC	2,198,502	$8,222	2.7%	$3.29	0.0%	COM NEW	78397T202
IKT	INHIBIKASE THERAPEUTICS INC	3,581,603	$7,342	2.4%	$1.59	0.0%	COM NEW	45719W205
ELVN	ENLIVEN THERAPEUTICS INC	446,084	$6,870	2.3%	$19.92	0.0%	COM	29337E102
NERV	MINERVA NEUROSCIENCES INC	1,655,500	$6,655	2.2%	$3.71	0.0%	COM NEW	603380205
ABVX	ABIVAX SA	49,119	$6,624	2.2%	$134.86	—	SPONSORED ADS	00370M103
HELP	CYBIN INC	770,000	$6,299	2.1%	$6.44	0.0%	COM NEW	23256X407
KALV	KALVISTA PHARMACEUTICALS INC	387,968	$6,266	2.1%	$13.24	0.0%	COM	483497103
ENTA	ENANTA PHARMACEUTICALS INC	389,687	$6,145	2.0%	$12.70	0.0%	COM	29251M106
ANRO	ALTO NEUROSCIENCE INC	222,844	$3,967	1.3%	$12.59	0.0%	COM SHS	02157Q109
LONA	ATHIRA PHARMA INC	393,701	$2,980	1.0%	$4.58	0.0%	COM	04746L203
CNTA	CENTESSA PHARMACEUTICALS PLC	77,997	$1,951	0.6%	$25.01	—	SPONSORED ADS	152309100
ALEC	ALECTOR INC	1,117,986	$1,744	0.6%	$1.77	0.0%	COM	014442107
LXEO	LEXEO THERAPEUTICS INC	175,000	$1,738	0.6%	$9.13	0.0%	COM	52886X107
IPSC	CENTURY THERAPEUTICS INC	1,421,532	$1,414	0.5%	$0.61	0.0%	COM	15673T100
STRO	SUTRO BIOPHARMA INC	75,594	$875	0.3%	$9.49	0.0%	COM SHS	869367201