| Nantahala Capital Management, LLC | 4,963,052 | $26,155 |
| BlackRock, Inc. | 3,159,863 | $16,652 |
| VANGUARD GROUP INC | 2,757,143 | $14,530 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,676,000 | $14,103 |
| Cable Car Capital, LP | 2,500,000 | $13,175 |
| AIGH Capital Management LLC | 2,000,000 | $10,540 |
| Vivo Capital, LLC | 1,842,751 | $9,711 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,137,127 | $5,994 |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,050,095 | $5,534 |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | $5,270 |
| NAN FUNG TRINITY (HK) LTD | 956,770 | $5,042 |
| STATE STREET CORP | 898,438 | $4,735 |
| Propel Bio Management, LLC | 830,780 | $4,378 |
| AWM Investment Company, Inc. | 774,130 | $4,080 |
| 683 Capital Management, LLC | 770,000 | $4,058 |
| Stonepine Capital Management, LLC | 709,505 | $3,739 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 701,288 | $3,696 |
| Diametric Capital, LP | 694,421 | $3,660 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 627,738 | $3,308 |
| abrdn plc | 616,413 | $3,248 |
| BALYASNY ASSET MANAGEMENT L.P. | 591,737 | $3,118 |
| CITIGROUP INC | 521,087 | $2,746 |
| BANK OF AMERICA CORP /DE/ | 507,625 | $2,675 |
| GOLDMAN SACHS GROUP INC | 502,184 | $2,647 |
| Simplify Asset Management Inc. | 500,342 | $2,637 |
| MORGAN STANLEY | 473,661 | $2,496 |
| NORTHERN TRUST CORP | 419,330 | $2,210 |
| J. Goldman & Co LP | 398,916 | $2,102 |
| Jain Global LLC | 366,067 | $1,929 |
| MILLENNIUM MANAGEMENT LLC | 343,568 | $1,811 |
| GROUP ONE TRADING, L.P. | 323,986 | $1,707 |
| Knoll Capital Management, LLC | 235,953 | $1,243 |
| Bank of New York Mellon Corp | 194,264 | $1,024 |
| Pale Fire Capital SE | 174,705 | $921 |
| FMR LLC | 168,455 | $888 |
| PANAGORA ASSET MANAGEMENT INC | 166,711 | $879 |
| UBS Group AG | 160,401 | $845 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 154,986 | $787 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,903 | $700 |
| CITADEL ADVISORS LLC | 127,618 | $673 |
| RENAISSANCE TECHNOLOGIES LLC | 116,200 | $612 |
| AQR CAPITAL MANAGEMENT LLC | 114,520 | $604 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 111,179 | $586 |
| Palo Alto Investors LP | 108,865 | $574 |
| D. E. Shaw & Co., Inc. | 105,965 | $558 |
| BARCLAYS PLC | 99,311 | $523 |
| SIMPLEX TRADING, LLC | 98,238 | $518 |
| Jump Financial, LLC | 75,940 | $400 |
| SEI INVESTMENTS CO | 71,153 | $375 |
| LPL Financial LLC | 62,873 | $331 |
| Rangeley Capital, LLC | 57,600 | $304 |
| Caption Management, LLC | 57,031 | $301 |
| Nuveen, LLC | 56,719 | $299 |
| RHUMBLINE ADVISERS | 55,931 | $295 |
| XTX Topco Ltd | 49,338 | $260 |
| WELLS FARGO & COMPANY/MN | 47,852 | $252 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 40,000 | $211 |
| DEUTSCHE BANK AG\ | 39,368 | $207 |
| AXQ CAPITAL, LP | 33,581 | $177 |
| Brooklyn Investment Group | 25,779 | $138 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,127 | $0 |
| MetLife Investment Management, LLC | 23,938 | $126 |
| Invesco Ltd. | 23,060 | $122 |
| Brevan Howard Capital Management LP | 21,707 | $114 |
| JPMORGAN CHASE & CO | 21,347 | $112 |
| INTECH INVESTMENT MANAGEMENT LLC | 21,249 | $112 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,242 | $107 |
| Riverwater Partners LLC | 19,375 | $102 |
| Cetera Investment Advisers | 18,258 | $96 |
| ALLIANCEBERNSTEIN L.P. | 17,920 | $94 |
| SHERBROOKE PARK ADVISERS LLC | 15,556 | $82 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,651 | $72 |
| ENVESTNET ASSET MANAGEMENT INC | 13,308 | $70 |
| Russell Investments Group, Ltd. | 13,095 | $69 |
| PVG ASSET MANAGEMENT CORP | 12,570 | $66 |
| Police & Firemen's Retirement System of New Jersey | 11,005 | $58 |
| SG Americas Securities, LLC | 10,731 | $0 |
| Truvestments Capital LLC | 10,307 | $54 |
| BNP PARIBAS ARBITRAGE, SA | 9,554 | $50 |
| MAI Capital Management | 5,620 | $30 |
| Legal & General Group Plc | 4,604 | $24 |
| Allworth Financial LP | 4,500 | $24 |
| Ameritas Investment Partners, Inc. | 4,459 | $23 |
| ROYAL BANK OF CANADA | 4,345 | $22 |
| Tower Research Capital LLC (TRC) | 3,662 | $19 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,689 | $14 |
| Farther Finance Advisors, LLC | 2,124 | $11 |
| OSAIC HOLDINGS, INC. | 1,901 | $10 |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,700 | $9 |
| SHP Wealth Management | 1,668 | $9 |
| AMALGAMATED BANK | 1,372 | $0 |
| Rockefeller Capital Management L.P. | 1,250 | $7 |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | $5 |
| Sterling Capital Management LLC | 427 | $2 |
| Parallel Advisors, LLC | 400 | $2 |
| Vermillion & White Wealth Management Group, LLC | 370 | $2 |
| UBS ASSET MANAGEMENT AMERICAS INC | 134 | $1 |
| GAMMA Investing LLC | 90 | $0 |
| SBI Securities Co., Ltd. | 78 | $0 |
| CWM, LLC | 55 | $0 |
| 3 other institutions | 32 | $0 |