| TCG Crossover Management, LLC | 7,111,596 | $959,034 |
| UBS Group AG | 4,423,906 | $596,586 |
| Darwin Global Management, Ltd. | 3,178,501 | $439,714 |
| MORGAN STANLEY | 3,151,994 | $425,062 |
| Point72 Asset Management, L.P. | 2,409,154 | $324,886 |
| Vestal Point Capital, LP | 1,900,000 | $256,225 |
| Caligan Partners LP | 1,451,924 | $195,799 |
| Paradigm Biocapital Advisors LP | 1,417,473 | $191,153 |
| FMR LLC | 1,365,657 | $184,166 |
| Cormorant Asset Management, LP | 1,350,000 | $182,054 |
| ADAR1 Capital Management, LLC | 1,317,329 | $177,648 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,009,966 | $136,199 |
| BAKER BROS. ADVISORS LP | 875,796 | $118,105 |
| LORD, ABBETT & CO. LLC | 849,732 | $115 |
| DEUTSCHE BANK AG\ | 764,899 | $103,154 |
| Octagon Capital Advisors LP | 756,000 | $101,950 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 754,836 | $101,793 |
| MILLENNIUM MANAGEMENT LLC | 741,060 | $99,936 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 691,973 | $93,316 |
| JANUS HENDERSON GROUP PLC | 667,761 | $90,038 |
| Eversept Partners, LP | 657,834 | $88,712 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 651,644 | $88 |
| Saturn V Capital Management LP | 649,179 | $87,545 |
| Artia Global Partners LP | 600,747 | $81,014 |
| CITADEL ADVISORS LLC | 563,747 | $76,024 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | $74,170 |
| BANK OF AMERICA CORP /DE/ | 522,289 | $70,433 |
| Ensign Peak Advisors, Inc | 518,347 | $69,902 |
| BVF INC/IL | 508,031 | $68,511 |
| BOOTHBAY FUND MANAGEMENT, LLC | 507,881 | $68,490 |
| Affinity Asset Advisors, LLC | 505,000 | $68,102 |
| PERCEPTIVE ADVISORS LLC | 458,343 | $61,810 |
| Jefferies Financial Group Inc. | 457,325 | $61,673 |
| JPMORGAN CHASE & CO | 455,923 | $61,483 |
| FRANKLIN RESOURCES INC | 449,121 | $60,566 |
| BlackRock, Inc. | 436,713 | $58,893 |
| abrdn plc | 426,658 | $57,537 |
| JANE STREET GROUP, LLC | 423,257 | $57,078 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 422,193 | $56,935 |
| Logos Global Management LP | 400,000 | $53,942 |
| STEMPOINT CAPITAL LP | 391,783 | $52,834 |
| FARALLON CAPITAL MANAGEMENT LLC | 387,000 | $52,189 |
| First Turn Management, LLC | 381,233 | $51,411 |
| Frazier Life Sciences Management, L.P. | 378,300 | $51,016 |
| ORBIMED ADVISORS LLC | 367,900 | $49,613 |
| Vivo Capital, LLC | 359,305 | $48,454 |
| BALYASNY ASSET MANAGEMENT L.P. | 358,322 | $48,322 |
| EVENTIDE ASSET MANAGEMENT, LLC | 327,911 | $44,221 |
| BARCLAYS PLC | 308,789 | $41,642 |
| GOLDMAN SACHS GROUP INC | 263,533 | $35,539 |
| Holocene Advisors, LP | 258,657 | $34,881 |
| Woodline Partners LP | 225,892 | $30,463 |
| Evergreen Quality Fund GP, Ltd. | 224,300 | $30,248 |
| PRINCIPAL FINANCIAL GROUP INC | 217,890 | $29,384 |
| ExodusPoint Capital Management, LP | 215,273 | $29,031 |
| Hudson Bay Capital Management LP | 208,219 | $28,079 |
| Ikarian Capital, LLC | 205,985 | $29,130 |
| Nantahala Capital Management, LLC | 153,235 | $20,665 |
| Squadron Capital Management LLC | 145,000 | $19,554 |
| Patient Square Capital LP | 130,000 | $17,531 |
| TimesSquare Capital Management, LLC | 129,384 | $17,448 |
| JENNISON ASSOCIATES LLC | 127,907 | $17,249 |
| Invesco Ltd. | 125,403 | $16,911 |
| Boxer Capital Management, LLC | 125,000 | $16,857 |
| Pictet Asset Management Holding SA | 124,449 | $16,783 |
| NAN FUNG TRINITY (HK) LTD | 113,365 | $15,288 |
| FEDERATED HERMES, INC. | 108,200 | $14,591 |
| Voleon Capital Management LP | 105,386 | $14,212 |
| Creek Drive Management Group LLC | 103,500 | $13,957 |
| Catalio Capital Management, LP | 98,514 | $13,285 |
| READYSTATE ASSET MANAGEMENT LP | 95,729 | $12,910 |
| LMR Partners LLP | 94,552 | $12,751 |
| APIS CAPITAL ADVISORS, LLC | 89,000 | $12,002 |
| First Light Asset Management, LLC | 88,674 | $11,958 |
| SEI INVESTMENTS CO | 87,153 | $11,749 |
| SAMLYN CAPITAL, LLC | 84,286 | $11,366 |
| Nicholas Investment Partners, LP | 83,068 | $11,202 |
| ODDO BHF ASSET MANAGEMENT SAS | 79,350 | $10,701 |
| Andera Partners | 78,125 | $10,536 |
| DIADEMA PARTNERS LP | 75,644 | $10,201 |
| Samsara BioCapital, LLC | 75,442 | $10,174 |
| HighVista Strategies LLC | 72,185 | $9,735 |
| Ally Bridge Group (NY) LLC | 70,000 | $9,440 |
| AMERIPRISE FINANCIAL INC | 67,665 | $9,125 |
| Velan Capital Investment Management LP | 67,000 | $9,035 |
| Resolute Capital Asset Partners LLC | 65,000 | $8,766 |
| Russell Investments Group, Ltd. | 64,473 | $8,695 |
| TD Asset Management Inc | 63,902 | $8,618 |
| ACT CAPITAL MANAGEMENT, LLC | 63,900 | $8,617 |
| LPL Financial LLC | 62,842 | $8,475 |
| Verition Fund Management LLC | 61,317 | $8,269 |
| MARSHALL WACE, LLP | 59,758 | $8,058 |
| MPM BioImpact LLC | 56,316 | $7,594 |
| SummitTX Capital, L.P. | 56,174 | $7,575 |
| Atika Capital Management LLC | 55,000 | $7,417 |
| Y-Intercept (Hong Kong) Ltd | 54,993 | $7,416 |
| Erste Asset Management GmbH | 50,000 | $7,020 |
| GEODE CAPITAL MANAGEMENT, LLC | 49,933 | $6,734 |
| Spruce Street Capital LP | 49,119 | $6,624 |
| Davern Capital Partners, LP | 48,502 | $6,541 |
| 146 other institutions | 1,191,050 | $155,662 |