ADAMAS PHARMACEUTICALS INC

CUSIP: 00548A106 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018
Shares 213,625 Value ($000) $5,518 Avg Close — Range —
Q1 2018
Shares 335,500 Value ($000) $8,018 Avg Close — Range —
Q4 2017
Shares 140,500 Value ($000) $4,762 Avg Close — Range —
Q3 2017
Shares 115,500 Value ($000) $2,445 Avg Close — Range —
Q2 2017
Shares 195,500 Value ($000) $3,419 Avg Close — Range —
Q1 2017
Shares 195,500 Value ($000) $3,421 Avg Close — Range —
Q4 2016
Shares 270,000 Value ($000) $4,563 Avg Close — Range —
Q3 2016
Shares 270,000 Value ($000) $4,431 Avg Close — Range —
Q2 2016
Shares 270,000 Value ($000) $4,088 Avg Close — Range —
Q1 2016
Shares 270,000 Value ($000) $3,904 Avg Close — Range —
Q4 2015
Shares 150,000 Value ($000) $4,248 Avg Close — Range —