SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q1 2026 (← Previous) (Next →)

Filing Date: May 15, 2026

Total Value: $630M (100.0% shares, 0.0% debt)

Holdings (96)

MLYS MINERALYS THERAPEUTICS INC 5.8%
Value $36.3M Shares 1,339,971 Est. Cost $29.70 Unrealized +5.6%
TEVA TEVA PHARMACEUTICAL INDS LTD 5.4%
Value $34.25M Shares 1,136,975 Est. Cost $15.30 Unrealized
TSEM TOWER SEMICONDUCTOR LTD 4.1%
Value $25.57M Shares 145,735 Est. Cost $54.51 Unrealized +136.4%
XBI SPDR SERIES TRUST 4.1%
Value $25.55M Shares 200,000 Est. Cost Unrealized
NVMI NOVA LTD 3.7%
Value $23.18M Shares 53,366 Est. Cost $245.13 Unrealized +78.9%
BBIO BRIDGEBIO PHARMA INC 2.9%
Value $18.21M Shares 245,246 Est. Cost $63.86 Unrealized +16.6%
CYTK CYTOKINETICS INC 2.7%
Value $17.09M Shares 259,300 Est. Cost $40.28 Unrealized +60.0%
BIIB BIOGEN INC 2.7%
Value $16.96M Shares 92,526 Est. Cost $159.11 Unrealized +15.2%
RARE ULTRAGENYX PHARMACEUTICAL IN 2.7%
Value $16.96M Shares 809,333 Est. Cost $27.53 Unrealized -15.2%
SNDX SYNDAX PHARMACEUTICALS INC 2.7%
Value $16.93M Shares 724,563 Est. Cost $17.41 Unrealized +19.2%
COGT COGENT BIOSCIENCES INC 2.5%
Value $16.02M Shares 416,340 Est. Cost $24.16 Unrealized +54.7%
SNY SANOFI SA 2.1%
Value $12.99M Shares 269,515 Est. Cost $46.50 Unrealized
AZN ASTRAZENECA PLC 2.0%
Value $12.33M Shares 62,530 Est. Cost $190.39 Unrealized 0.0%
FOLD AMICUS THERAPEUTIC 1.4%
Value $8.725M Shares 603,377 Est. Cost $6.45 Unrealized +121.7%
CLBT CELLEBRITE DI LTD 1.4%
Value $8.702M Shares 631,521 Est. Cost $15.55 Unrealized 0.0%
APLS APELLIS PHARMACEUTICALS INC 1.4%
Value $8.646M Shares 214,914 Est. Cost $26.90 Unrealized -15.7%
PANW PALO ALTO NETWORKS INC 1.3%
Value $8.465M Shares 52,800 Est. Cost $172.15 Unrealized 0.0%
LLY ELI LILLY & CO 1.3%
Value $8.315M Shares 9,040 Est. Cost $258.77 Unrealized +304.6%
BCRX BIOCRYST PHARMACEUTICALS INC 1.3%
Value $8.249M Shares 866,464 Est. Cost $7.22 Unrealized -3.1%
CAMT CAMTEK LTD 1.3%
Value $8.038M Shares 53,020 Est. Cost $107.76 Unrealized +35.4%
BMRN BIOMARIN PHARMACEUTICAL INC 1.3%
Value $7.903M Shares 139,900 Est. Cost $54.44 Unrealized +7.9%
CLDX CELLDEX THERAPEUTICS INC NEW 1.2%
Value $7.726M Shares 243,575 Est. Cost $31.46 Unrealized -19.2%
ORA ORMAT TECHNOLOGIES INC 1.2%
Value $7.639M Shares 68,250 Est. Cost $120.51 Unrealized 0.0%
XENE XENON PHARMACEUTICALS INC 1.2%
Value $7.385M Shares 127,000 Est. Cost $41.98 Unrealized 0.0%
SLNO SOLENO THERAPEUTICS INC 1.1%
Value $7.241M Shares 216,281 Est. Cost $53.66 Unrealized -22.4%
TNGX TANGO THERAPEUTICS INC 1.1%
Value $7.187M Shares 343,563 Est. Cost $8.62 Unrealized +38.2%
JNJ JOHNSON & JOHNSON 1.1%
Value $7.047M Shares 28,831 Est. Cost $136.97 Unrealized +66.4%
SOLAREDGE TECHNOLOGIES INC 1.1%
Value $6.91M Shares 4,000,000 Est. Cost $1.33 Unrealized
IMTX IMMATICS N.V 1.1%
Value $6.85M Shares 696,105 Est. Cost $10.79 Unrealized -9.1%
TRVI TREVI THERAPEUTICS INC 1.1%
Value $6.848M Shares 574,029 Est. Cost $6.22 Unrealized +75.9%
ORIC ORIC PHARMACEUTICALS INC 1.1%
Value $6.812M Shares 537,628 Est. Cost $10.24 Unrealized +5.1%
MAZE MAZE THERAPEUTICS INC 1.1%
Value $6.786M Shares 227,343 Est. Cost $33.93 Unrealized +29.8%
GSK GSK PLC 1.1%
Value $6.733M Shares 122,000 Est. Cost $35.22 Unrealized
AMZN AMAZON COM INC 1.1%
Value $6.652M Shares 31,940 Est. Cost $226.83 Unrealized 0.0%
ABBV ABBVIE INC 1.0%
Value $6.58M Shares 30,256 Est. Cost $115.16 Unrealized +93.3%
AAOI APPLIED OPTOELECTRONICS INC 1.0%
Value $6.209M Shares 73,400 Est. Cost $41.81 Unrealized 0.0%
ELVN ENLIVEN THERAPEUTICS INC 1.0%
Value $6.008M Shares 153,265 Est. Cost $20.68 Unrealized +23.8%
MRK MERCK & CO INC 0.9%
Value $5.846M Shares 48,600 Est. Cost $73.08 Unrealized +56.4%
VOR VOR BIOPHARMA INC 0.9%
Value $5.743M Shares 321,917 Est. Cost $18.62 Unrealized -24.9%
ACAD ACADIA PHARMACEUTICALS INC 0.9%
Value $5.703M Shares 256,202 Est. Cost $21.04 Unrealized +19.8%
NVS NOVARTIS AG 0.9%
Value $5.652M Shares 37,000 Est. Cost $92.00 Unrealized
ELDN ELEDON PHARMACEUTICALS INC 0.9%
Value $5.458M Shares 1,772,131 Est. Cost $2.84 Unrealized -26.6%
ENPH ENPHASE ENERGY INC 0.9%
Value $5.385M Shares 142,419 Est. Cost $33.07 Unrealized +24.7%
RVMD REVOLUTION MEDICINES INC 0.9%
Value $5.359M Shares 55,110 Est. Cost $42.18 Unrealized +144.2%
PFE PFIZER INC 0.8%
Value $5.223M Shares 186,000 Est. Cost $30.97 Unrealized -15.5%
BHVN BIOHAVEN LTD 0.8%
Value $5.025M Shares 594,000 Est. Cost $11.75 Unrealized 0.0%
FBRX FORTE BIOSCIENCES INC 0.8%
Value $4.791M Shares 184,984 Est. Cost $8.61 Unrealized +244.8%
HELP CYBIN INC 0.8%
Value $4.738M Shares 987,090 Est. Cost $7.84 Unrealized -9.4%
MDGL MADRIGAL PHARMACEUTICALS INC 0.8%
Value $4.732M Shares 9,040 Est. Cost $499.16 Unrealized -1.3%
SRRK SCHOLAR ROCK HLDG CORP 0.7%
Value $4.634M Shares 94,265 Est. Cost $37.51 Unrealized +21.2%
NVO NOVO-NORDISK A S 0.7%
Value $4.435M Shares 120,677 Est. Cost $88.07 Unrealized
MDWD MEDIWOUND LTD 0.7%
Value $4.401M Shares 273,192 Est. Cost $18.30 Unrealized -3.1%
KOD KODIAK SCIENCES INC 0.7%
Value $4.376M Shares 114,796 Est. Cost $20.48 Unrealized +24.1%
ZBIO ZENAS BIOPHARMA INC 0.7%
Value $4.19M Shares 214,334 Est. Cost $21.89 Unrealized 0.0%
PMN PROMIS NEUROSCIENCES INC 0.7%
Value $4.135M Shares 325,591 Est. Cost $12.08 Unrealized +0.7%
TLT ISHARES TR 0.6%
Value $4.074M Shares 47,000 Est. Cost Unrealized
RLAY RELAY THERAPEUTICS INC 0.6%
Value $4.064M Shares 408,436 Est. Cost $8.30 Unrealized 0.0%
SVRA SAVARA INC 0.6%
Value $4.036M Shares 739,164 Est. Cost $3.82 Unrealized +49.1%
WVE WAVE LIFE SCIENCES LTD 0.6%
Value $3.975M Shares 548,272 Est. Cost $10.89 Unrealized +26.3%
CRVS CORVUS PHARMACEUTICALS INC 0.6%
Value $3.628M Shares 247,961 Est. Cost $6.17 Unrealized +163.9%
OVID OVID THERAPEUTICS INC 0.6%
Value $3.603M Shares 1,622,828 Est. Cost $1.60 Unrealized 0.0%
IRON DISC MEDICINE INC 0.5%
Value $3.423M Shares 53,538 Est. Cost $74.04 Unrealized 0.0%
UPB UPSTREAM BIO INC 0.5%
Value $3.222M Shares 358,000 Est. Cost $23.68 Unrealized 0.0%
ACOG ALPHA COGNITION INC 0.5%
Value $3.116M Shares 567,616 Est. Cost $5.90 Unrealized -3.9%
PALI PALISADE BIO INC 0.5%
Value $3.034M Shares 1,733,471 Est. Cost $1.80 Unrealized -0.8%
DYN DYNE THERAPEUTICS INC 0.5%
Value $2.912M Shares 160,594 Est. Cost $19.51 Unrealized -12.3%
CLYM CLIMB BIO INC 0.5%
Value $2.872M Shares 419,247 Est. Cost $3.04 Unrealized +64.5%
ZIM ZIM INTEGRATED SHIPPING SERV 0.4%
Value $2.792M Shares 105,950 Est. Cost $16.77 Unrealized +39.7%
MSLE SATELLOS BIOSCIENCE INC 0.4%
Value $2.754M Shares 489,207 Est. Cost $5.63 Unrealized
SEDG SOLAREDGE TECHNOLOGIES INC 0.4%
Value $2.697M Shares 52,836 Est. Cost $21.86 Unrealized +59.0%
AMGN AMGEN INC 0.4%
Value $2.639M Shares 7,500 Est. Cost $287.24 Unrealized +21.7%
CYTK CYTOKINETICS INC 0.4%
Value $2.624M Shares 39,817 Est. Cost $40.28 Unrealized +60.0%
GPCR STRUCTURE THERAPEUTICS INC 0.4%
Value $2.449M Shares 50,800 Est. Cost $27.33 Unrealized
KURA KURA ONCOLOGY INC 0.4%
Value $2.403M Shares 295,522 Est. Cost $16.72 Unrealized -48.5%
GENB GENERATE BIOMEDICINES INC 0.4%
Value $2.313M Shares 185,000 Est. Cost $12.50 Unrealized
IBIT ISHARES BITCOIN TRUST ETF 0.4%
Value $2.286M Shares 59,505 Est. Cost $46.29 Unrealized
CTNM CONTINEUM THERAPEUTICS INC 0.4%
Value $2.266M Shares 173,475 Est. Cost $11.41 Unrealized +17.0%
TENX TENAX THERAPEUTICS INC 0.3%
Value $2.175M Shares 136,015 Est. Cost $8.70 Unrealized +55.2%
PRLD PRELUDE THERAPEUTICS INC 0.3%
Value $1.91M Shares 558,339 Est. Cost $2.17 Unrealized +6.2%
ASND ASCENDIS PHARMA A/S 0.3%
Value $1.83M Shares 8,000 Est. Cost $213.24 Unrealized
VSTM VERASTEM INC 0.3%
Value $1.821M Shares 343,678 Est. Cost $8.31 Unrealized -22.1%
VYGR VOYAGER THERAPEUTICS INC 0.3%
Value $1.813M Shares 469,761 Est. Cost $4.23 Unrealized
STTK SHATTUCK LABS INC 0.3%
Value $1.805M Shares 280,786 Est. Cost $2.92 Unrealized +42.0%
EVMN EVOMMUNE INC 0.3%
Value $1.799M Shares 78,234 Est. Cost $18.78 Unrealized +17.1%
BIOA BIOAGE LABS INC 0.2%
Value $1.513M Shares 86,518 Est. Cost $8.86 Unrealized +116.6%
OLMA OLEMA PHARMACEUTICALS INC 0.2%
Value $1.491M Shares 100,000 Est. Cost Unrealized
ORGO ORGANOGENESIS HLDGS INC 0.2%
Value $1.304M Shares 550,000 Est. Cost $3.99 Unrealized 0.0%
CRIS CURIS INC 0.2%
Value $1.092M Shares 1,994,937 Est. Cost $0.98 Unrealized 0.0%
BMY BRISTOL-MYERS SQUIBB CO 0.2%
Value $1.061M Shares 17,500 Est. Cost $52.58 Unrealized +9.2%
CTMX CYTOMX THERAPEUTICS INC. 0.2%
Value $1.034M Shares 220,000 Est. Cost $5.23 Unrealized 0.0%
NICE NICE LTD 0.1%
Value $619K Shares 5,611 Est. Cost $110.26 Unrealized
HOWL WEREWOLF THERAPEUTICS INC 0.1%
Value $522K Shares 626,810 Est. Cost $13.12 Unrealized -95.1%
SKYE SKYE BIOSCIENCE INC 0.1%
Value $417K Shares 678,928 Est. Cost $7.87 Unrealized -88.6%
DTIL PRECISION BIOSCIENCES INC 0.0%
Value $220K Shares 40,000 Est. Cost $5.68 Unrealized -29.6%
APRE APREA THERAPEUTICS INC 0.0%
Value $206K Shares 270,000 Est. Cost $6.22 Unrealized -87.4%
FHTX FOGHORN THERAPEUTICS INC 0.0%
Value $58,431 Shares 12,224 Est. Cost $5.69 Unrealized 0.0%