| ORBIMED ADVISORS LLC | 1,027,944 | $8,655 |
| RA CAPITAL MANAGEMENT, L.P. | 948,249 | $7,984 |
| FRANKLIN RESOURCES INC | 626,571 | $5,276 |
| Woodline Partners LP | 625,000 | $5,263 |
| VANGUARD GROUP INC | 291,277 | $2,453 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 274,375 | $2,310 |
| Prosight Management, LP | 250,244 | $2,107 |
| RENAISSANCE TECHNOLOGIES LLC | 242,945 | $2,046 |
| GOLDMAN SACHS GROUP INC | 234,510 | $1,975 |
| Stonepine Capital Management, LLC | 220,011 | $1,852 |
| Alyeska Investment Group, L.P. | 203,799 | $1,716 |
| Carlyle Group Inc. | 184,295 | $1,544 |
| ACADIAN ASSET MANAGEMENT LLC | 181,395 | $2 |
| NEXTBio Capital Management LP | 157,827 | $1,329 |
| TWO SIGMA INVESTMENTS, LP | 144,796 | $1,219 |
| ADAR1 Capital Management, LLC | 128,646 | $1,083 |
| TWO SIGMA ADVISERS, LP | 111,336 | $937 |
| CITADEL ADVISORS LLC | 107,814 | $908 |
| DAFNA Capital Management LLC | 93,812 | $790 |
| GEODE CAPITAL MANAGEMENT, LLC | 88,856 | $748 |
| Burkehill Global Management, LP | 62,500 | $526 |
| LUMINUS MANAGEMENT LLC | 59,558 | $501 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56,350 | $474 |
| Squarepoint Ops LLC | 55,723 | $469 |
| RBF Capital, LLC | 38,582 | $325 |
| BlackRock, Inc. | 36,585 | $308 |
| Maven Securities LTD | 31,250 | $263 |
| STATE STREET CORP | 25,896 | $218 |
| Rangeley Capital, LLC | 25,001 | $211 |
| BARCLAYS PLC | 25,000 | $211 |
| JOHNSON & JOHNSON | 22,779 | $192 |
| XTX Topco Ltd | 18,610 | $157 |
| GSA CAPITAL PARTNERS LLP | 17,763 | $0 |
| NORTHERN TRUST CORP | 14,067 | $118 |
| TANG CAPITAL MANAGEMENT LLC | 6,158 | $52 |
| FNY Investment Advisers, LLC | 6,100 | $0 |
| ROYAL BANK OF CANADA | 5,449 | $46 |
| UBS Group AG | 3,797 | $32 |
| MORGAN STANLEY | 3,040 | $26 |
| BANK OF AMERICA CORP /DE/ | 1,288 | $11 |
| Tower Research Capital LLC (TRC) | 1,072 | $9 |
| HOLLENCREST CAPITAL MANAGEMENT | 250 | $2 |
| SIMPLEX TRADING, LLC | 87 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 50 | $0 |
| FMR LLC | 34 | $0 |
| SBI Securities Co., Ltd. | 19 | $0 |
| JPMORGAN CHASE & CO | 12 | $0 |
| DANSKE BANK A/S | 1 | $0 |