SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Virtus Investment Advisers, LLC's Holding History (CIK: 0000019481)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 7,913 Value ($000) $259 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 6,425 Value ($000) $108 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 5,310 Value ($000) $79 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 6,861 Value ($000) $111 Avg Close $20.81 Range $16.13 - $26.01

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	7,913	$259	$26.13	$15.86 - $35.31
Q3 2025	6,425	$108	$16.31	$14.00 - $18.30
Q2 2025	5,310	$79	$14.80	$10.91 - $19.20
Q1 2025	6,861	$111	$20.81	$16.13 - $26.01