| FMR LLC | 11,638,819 | $381,288 |
| BlackRock, Inc. | 5,522,101 | $180,904 |
| RTW INVESTMENTS, LP | 4,171,996 | $136,675 |
| VANGUARD GROUP INC | 4,035,074 | $132,189 |
| Fairmount Funds Management LLC | 4,018,101 | $131,633 |
| VR Adviser, LLC | 3,685,448 | $120,735 |
| Capital International Investors | 3,492,541 | $114,416 |
| PERCEPTIVE ADVISORS LLC | 3,069,225 | $100,548 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,882,420 | $94,428 |
| Commodore Capital LP | 2,388,245 | $78,239 |
| STATE STREET CORP | 2,262,839 | $74,131 |
| TCG Crossover Management, LLC | 1,900,582 | $62,263 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | $61,988 |
| JANUS HENDERSON GROUP PLC | 1,829,009 | $59,918 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,659,140 | $54,362 |
| BRAIDWELL LP | 1,634,615 | $53,550 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | $53,124 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,601,882 | $52 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,549,284 | $50,755 |
| Paradigm Biocapital Advisors LP | 1,467,266 | $48,068 |
| Remedium Capital Partners, LLC | 1,456,231 | $48 |
| Affinity Asset Advisors, LLC | 1,432,591 | $46,932 |
| FRANKLIN RESOURCES INC | 1,109,274 | $36,340 |
| BAKER BROS. ADVISORS LP | 1,000,000 | $32,760 |
| Pictet Asset Management Holding SA | 913,960 | $29,941 |
| Siren, L.L.C. | 818,598 | $26,817 |
| Polar Capital Holdings Plc | 740,326 | $24,253 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 710,626 | $23,280 |
| UBS Group AG | 680,566 | $22,295 |
| Point72 Asset Management, L.P. | 662,351 | $21,699 |
| EMERALD ADVISERS, LLC | 636,109 | $20,839 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 574,622 | $18,825 |
| NORTHERN TRUST CORP | 561,023 | $18,379 |
| Blackstone Inc. | 500,998 | $16,413 |
| Candriam S.C.A. | 425,534 | $13,941 |
| BANK OF AMERICA CORP /DE/ | 419,727 | $13,750 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 412,371 | $13,509 |
| GOLDMAN SACHS GROUP INC | 275,065 | $9,011 |
| Woodline Partners LP | 265,892 | $8,711 |
| Capital World Investors | 200,172 | $6,558 |
| ARMISTICE CAPITAL, LLC | 196,426 | $6,435 |
| Bank of New York Mellon Corp | 192,830 | $6,317 |
| HighVista Strategies LLC | 188,206 | $6,166 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 187,737 | $6,150 |
| MORGAN STANLEY | 182,734 | $5,986 |
| BARCLAYS PLC | 182,524 | $5,979 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 171,211 | $5,609 |
| Nuveen, LLC | 150,980 | $4,946 |
| Invesco Ltd. | 150,934 | $4,945 |
| Patient Square Capital LP | 150,000 | $4,914 |
| TD Asset Management Inc | 149,822 | $4,908 |
| VICTORY CAPITAL MANAGEMENT INC | 146,079 | $4,786 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 129,013 | $4,144 |
| Parkman Healthcare Partners LLC | 124,485 | $4,078 |
| DEUTSCHE BANK AG\ | 121,941 | $3,995 |
| MERCER GLOBAL ADVISORS INC /ADV | 106,316 | $3,483 |
| F/M Investments LLC | 103,718 | $3,398 |
| CITIGROUP INC | 100,058 | $3,278 |
| SEVEN GRAND MANAGERS, LLC | 100,000 | $3,276 |
| B Group, Inc. | 100,000 | $3,276 |
| Swiss National Bank | 96,500 | $3,161 |
| RHUMBLINE ADVISERS | 82,956 | $2,718 |
| WELLS FARGO & COMPANY/MN | 82,416 | $2,700 |
| DIMENSIONAL FUND ADVISORS LP | 77,290 | $2,532 |
| MILLENNIUM MANAGEMENT LLC | 76,194 | $2,496 |
| BALYASNY ASSET MANAGEMENT L.P. | 73,465 | $2,407 |
| ALLIANCEBERNSTEIN L.P. | 67,500 | $2,211 |
| CITADEL ADVISORS LLC | 63,904 | $2,093 |
| ALPS ADVISORS INC | 63,708 | $2,087 |
| JPMORGAN CHASE & CO | 62,951 | $2,062 |
| UBS ASSET MANAGEMENT AMERICAS INC | 62,216 | $2,038 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 61,574 | $1,963 |
| Legal & General Group Plc | 56,448 | $1,849 |
| Rafferty Asset Management, LLC | 53,410 | $1,750 |
| Susquehanna Portfolio Strategies, LLC | 53,101 | $1,740 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,038 | $1,574 |
| AMERIPRISE FINANCIAL INC | 38,256 | $1,253 |
| MetLife Investment Management, LLC | 38,011 | $1,245 |
| ExodusPoint Capital Management, LP | 37,871 | $1,241 |
| Cinctive Capital Management LP | 35,935 | $1,177 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,144 | $1,149 |
| ADAR1 Capital Management, LLC | 34,051 | $1,116 |
| STEMPOINT CAPITAL LP | 32,377 | $1,061 |
| Voya Investment Management LLC | 27,277 | $894 |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,252 | $893 |
| Waverly Advisors, LLC | 25,954 | $850 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 25,799 | $1 |
| Optimize Financial Inc | 25,331 | $830 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 24,950 | $817 |
| SG Americas Securities, LLC | 23,343 | $1 |
| Assenagon Asset Management S.A. | 22,136 | $725 |
| PROFUND ADVISORS LLC | 20,593 | $675 |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,165 | $628 |
| Police & Firemen's Retirement System of New Jersey | 18,360 | $601 |
| INTECH INVESTMENT MANAGEMENT LLC | 18,274 | $599 |
| Neo Ivy Capital Management | 18,261 | $598 |
| Global Endowment Management, LP | 18,184 | $596 |
| AQR CAPITAL MANAGEMENT LLC | 17,820 | $584 |
| State of New Jersey Common Pension Fund D | 16,698 | $547 |
| ProShare Advisors LLC | 15,989 | $524 |
| 53 other institutions | 224,725 | $7,035 |