SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

Jefferies Financial Group Inc.'s Holding History (CIK: 0000096223)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 1,388,854 Value ($000) $23,277 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 1,388,854 Value ($000) $20,791 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 1,248,854 Value ($000) $20,150 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 1,216,954 Value ($000) $28,331 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 454,807 Value ($000) $13,376 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 97,573 Value ($000) $2,294 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	1,388,854	$23,277	$16.31	$14.00 - $18.30
Q2 2025	1,388,854	$20,791	$14.80	$10.91 - $19.20
Q1 2025	1,248,854	$20,150	$20.81	$16.13 - $26.01
Q4 2024	1,216,954	$28,331	$29.32	$22.37 - $40.26
Q3 2024	454,807	$13,376	$27.85	$23.00 - $32.41
Q2 2024	97,573	$2,294	$33.73	$22.19 - $40.84