SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

BARCLAYS PLC's Holding History (CIK: 0000312069)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 182,524 Value ($000) $5,979 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 105,467 Value ($000) $3,102 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 216,646 Value ($000) $3,243 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 214,606 Value ($000) $3,463 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 123,071 Value ($000) $2,865 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 105,467 Value ($000) $3 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 64,043 Value ($000) $1,506 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 45,962 Value ($000) $1,743 Avg Close $28.97 Range $18.54 - $47.97

Q4 2023

Shares 45,498 Value ($000) $979 Avg Close $13.78 Range $8.43 - $22.66

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	182,524	$5,979	$26.13	$15.86 - $35.31
Q3 2025	105,467	$3,102	$16.31	$14.00 - $18.30
Q2 2025	216,646	$3,243	$14.80	$10.91 - $19.20
Q1 2025	214,606	$3,463	$20.81	$16.13 - $26.01
Q4 2024	123,071	$2,865	$29.32	$22.37 - $40.26
Q3 2024	105,467	$3	$27.85	$23.00 - $32.41
Q2 2024	64,043	$1,506	$33.73	$22.19 - $40.84
Q1 2024	45,962	$1,743	$28.97	$18.54 - $47.97
Q4 2023	45,498	$979	$13.78	$8.43 - $22.66