SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

CHARLES SCHWAB INVESTMENT MANAGEMENT INC's Holding History (CIK: 0000884546)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 574,622 Value ($000) $18,825 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 425,345 Value ($000) $7,129 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 418,503 Value ($000) $6,265 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 382,636 Value ($000) $6,174 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 379,650 Value ($000) $8,838 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 333,275 Value ($000) $9,802 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 98,181 Value ($000) $2,308 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 15,000 Value ($000) $569 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	574,622	$18,825	$26.13	$15.86 - $35.31
Q3 2025	425,345	$7,129	$16.31	$14.00 - $18.30
Q2 2025	418,503	$6,265	$14.80	$10.91 - $19.20
Q1 2025	382,636	$6,174	$20.81	$16.13 - $26.01
Q4 2024	379,650	$8,838	$29.32	$22.37 - $40.26
Q3 2024	333,275	$9,802	$27.85	$23.00 - $32.41
Q2 2024	98,181	$2,308	$33.73	$22.19 - $40.84
Q1 2024	15,000	$569	$28.97	$18.54 - $47.97