SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

MORGAN STANLEY's Holding History (CIK: 0000895421)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 182,734 Value ($000) $5,986 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 334,722 Value ($000) $5,610 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 671,044 Value ($000) $10,046 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 335,467 Value ($000) $5,413 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 255,256 Value ($000) $5,942 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 243,742 Value ($000) $7,168 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 408,853 Value ($000) $9,612 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 51,188 Value ($000) $1,942 Avg Close $28.97 Range $18.54 - $47.97

Q4 2023

Shares 40 Value ($000) $1 Avg Close $13.78 Range $8.43 - $22.66

Q3 2023

Shares 46 Value ($000) $1 Avg Close $13.22 Range $9.53 - $18.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	182,734	$5,986	$26.13	$15.86 - $35.31
Q3 2025	334,722	$5,610	$16.31	$14.00 - $18.30
Q2 2025	671,044	$10,046	$14.80	$10.91 - $19.20
Q1 2025	335,467	$5,413	$20.81	$16.13 - $26.01
Q4 2024	255,256	$5,942	$29.32	$22.37 - $40.26
Q3 2024	243,742	$7,168	$27.85	$23.00 - $32.41
Q2 2024	408,853	$9,612	$33.73	$22.19 - $40.84
Q1 2024	51,188	$1,942	$28.97	$18.54 - $47.97
Q4 2023	40	$1	$13.78	$8.43 - $22.66
Q3 2023	46	$1	$13.22	$9.53 - $18.00