SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 129,013 Value ($000) $4,144 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 71,948 Value ($000) $1,206 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 79,896 Value ($000) $1,196 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 53,901 Value ($000) $870 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 52,762 Value ($000) $1,228 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 43,460 Value ($000) $1,278 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 37,782 Value ($000) $888 Avg Close $33.73 Range $22.19 - $40.84

Q1 2024

Shares 24,657 Value ($000) $935 Avg Close $28.97 Range $18.54 - $47.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	129,013	$4,144	$26.13	$15.86 - $35.31
Q3 2025	71,948	$1,206	$16.31	$14.00 - $18.30
Q2 2025	79,896	$1,196	$14.80	$10.91 - $19.20
Q1 2025	53,901	$870	$20.81	$16.13 - $26.01
Q4 2024	52,762	$1,228	$29.32	$22.37 - $40.26
Q3 2024	43,460	$1,278	$27.85	$23.00 - $32.41
Q2 2024	37,782	$888	$33.73	$22.19 - $40.84
Q1 2024	24,657	$935	$28.97	$18.54 - $47.97