SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

MARTINGALE ASSET MANAGEMENT L P's Holding History (CIK: 0000936944)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,930 Value ($000) $227 Avg Close $26.13 Range $15.86 - $35.31

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,930	$227	$26.13	$15.86 - $35.31