SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM's Holding History (CIK: 0000938076)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 9,030 Value ($000) $296 Avg Close $26.13 Range $15.86 - $35.31

Q4 2024

Shares 9,030 Value ($000) $210 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 9,030 Value ($000) $266 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 9,030 Value ($000) $212 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	9,030	$296	$26.13	$15.86 - $35.31
Q4 2024	9,030	$210	$29.32	$22.37 - $40.26
Q3 2024	9,030	$266	$27.85	$23.00 - $32.41
Q2 2024	9,030	$212	$33.73	$22.19 - $40.84