SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

DEERFIELD MANAGEMENT COMPANY, L.P.'s Holding History (CIK: 0001009258)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 710,626 Value ($000) $23,280 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 613,665 Value ($000) $10,285 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 613,665 Value ($000) $9,187 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 450,000 Value ($000) $7,261 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 450,000 Value ($000) $10,476 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	710,626	$23,280	$26.13	$15.86 - $35.31
Q3 2025	613,665	$10,285	$16.31	$14.00 - $18.30
Q2 2025	613,665	$9,187	$14.80	$10.91 - $19.20
Q1 2025	450,000	$7,261	$20.81	$16.13 - $26.01
Q4 2024	450,000	$10,476	$29.32	$22.37 - $40.26