SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

EMERALD ADVISERS, LLC's Holding History (CIK: 0001015083)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 636,109 Value ($000) $20,839 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 548,712 Value ($000) $9,196 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 565,863 Value ($000) $8,471 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 547,827 Value ($000) $8,839 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 546,791 Value ($000) $12,729 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 292,569 Value ($000) $8,604 Avg Close $27.85 Range $23.00 - $32.41

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	636,109	$20,839	$26.13	$15.86 - $35.31
Q3 2025	548,712	$9,196	$16.31	$14.00 - $18.30
Q2 2025	565,863	$8,471	$14.80	$10.91 - $19.20
Q1 2025	547,827	$8,839	$20.81	$16.13 - $26.01
Q4 2024	546,791	$12,729	$29.32	$22.37 - $40.26
Q3 2024	292,569	$8,604	$27.85	$23.00 - $32.41