SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

NATIXIS ADVISORS, L.P.'s Holding History (CIK: 0001018331)

Note: Option positions (PUT/CALL) are excluded.

Q1 2025

Shares 16,401 Value ($000) $0 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 17,300 Value ($000) $0 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2025	16,401	$0	$20.81	$16.13 - $26.01
Q4 2024	17,300	$0	$29.32	$22.37 - $40.26