SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

SCHRODER INVESTMENT MANAGEMENT GROUP's Holding History (CIK: 0001086619)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 61,574 Value ($000) $1,963 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 107,738 Value ($000) $1,763 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 129,558 Value ($000) $1,972 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 108,504 Value ($000) $1,947 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 113,620 Value ($000) $2,561 Avg Close $29.32 Range $22.37 - $40.26

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	61,574	$1,963	$26.13	$15.86 - $35.31
Q3 2025	107,738	$1,763	$16.31	$14.00 - $18.30
Q2 2025	129,558	$1,972	$14.80	$10.91 - $19.20
Q1 2025	108,504	$1,947	$20.81	$16.13 - $26.01
Q4 2024	113,620	$2,561	$29.32	$22.37 - $40.26