SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

ALLIANCEBERNSTEIN L.P.'s Holding History (CIK: 0001109448)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 67,500 Value ($000) $2,211 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 36,230 Value ($000) $607 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 36,230 Value ($000) $542 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 36,230 Value ($000) $585 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 36,230 Value ($000) $843 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 36,230 Value ($000) $1,066 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 36,230 Value ($000) $852 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	67,500	$2,211	$26.13	$15.86 - $35.31
Q3 2025	36,230	$607	$16.31	$14.00 - $18.30
Q2 2025	36,230	$542	$14.80	$10.91 - $19.20
Q1 2025	36,230	$585	$20.81	$16.13 - $26.01
Q4 2024	36,230	$843	$29.32	$22.37 - $40.26
Q3 2024	36,230	$1,066	$27.85	$23.00 - $32.41
Q2 2024	36,230	$852	$33.73	$22.19 - $40.84