SPYRE THERAPEUTICS INC

Ticker: SYRE CUSIP: 00773J202 Class: Common Stock

PROFUND ADVISORS LLC's Holding History (CIK: 0001129919)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 20,593 Value ($000) $675 Avg Close $26.13 Range $15.86 - $35.31

Q3 2025

Shares 13,223 Value ($000) $222 Avg Close $16.31 Range $14.00 - $18.30

Q2 2025

Shares 11,043 Value ($000) $165 Avg Close $14.80 Range $10.91 - $19.20

Q1 2025

Shares 14,662 Value ($000) $237 Avg Close $20.81 Range $16.13 - $26.01

Q4 2024

Shares 14,862 Value ($000) $346 Avg Close $29.32 Range $22.37 - $40.26

Q3 2024

Shares 14,075 Value ($000) $414 Avg Close $27.85 Range $23.00 - $32.41

Q2 2024

Shares 12,606 Value ($000) $296 Avg Close $33.73 Range $22.19 - $40.84

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	20,593	$675	$26.13	$15.86 - $35.31
Q3 2025	13,223	$222	$16.31	$14.00 - $18.30
Q2 2025	11,043	$165	$14.80	$10.91 - $19.20
Q1 2025	14,662	$237	$20.81	$16.13 - $26.01
Q4 2024	14,862	$346	$29.32	$22.37 - $40.26
Q3 2024	14,075	$414	$27.85	$23.00 - $32.41
Q2 2024	12,606	$296	$33.73	$22.19 - $40.84